Biochemical metabolites are implicated in
preeclampsia, which include elevated plasma concentration of Triglycerides (TG), Low Density Lipoprotein Cholesterol (LDLC), total lipids and reduced High Density
Lipoprotein Cholesterol (HDLC)
concentrations and significant reductions in fasting plasma glucose, and serum insulin homeostasis model of assessment.
Vitamin D supplementation seems to be a possible target for intervention and
possible improved pregnancy outcomes in preeclampsia. Therefore, this study
aimed at determining the effects of Vitamin D supplementation on the Lipid
Profile, and random plasma glucose levels of preeclamptic women in Ibadan,
Nigeria. This interventional study was carried out at the Antenatal clinic of
Obstetrics and Gynecology Departments of University College Hospital Ibadan and Adeoyo Maternity Clinic, Yemetu, Ibadan, Nigeria. 120 pregnant women aged 18 to
35 were recruited; 40
normotensive pregnant women served as control;
40 randomly chosen preeclamptic women were placed on oral vitamin D
supplement of 1000 IU/day
for 8 weeks and 40 preeclamptic women were given no
supplement. Blood samples were taken at study baseline (22 weeks), after 8 weeks of supplementation (3rd trimester)
and 3 to 5 days postpartum in all groups to quantify serum vitamin D, random
glucose and Lipid profile. Vitamin D was quantified by Enzyme Linked
Immunosorbent Assay (ELISA), glucose status by glucose oxidase method and lipid
profile by standard methods. Statistical analysis was performed using
Statistical Package for Social Sciences (SPSS) soft version 17.0 and subjected
to One way analysis of Variance (ANOVA) and
Student’s t test. Results showed a significant increase (p < 0.05)
in levels of TG, LDLC, random plasma glucose and a decrease (p < 0.05) in HDLC levels in the
preeclamptic groups when compared with normotensive women in second and third
trimester. After vitamin D supplementation, there was a significant reduction (p < 0.05) in Total Cholesterol (TC), TG,
LDLC levels and an increase in HDLC (p < 0.05) (4.49 ± 0.38, 1.51 ± 0.22, 3.45 ± 0.57, 1.87 ± 0.29) vs. (5.96 ± 0.49, 2.30 ± 0.20, 5.90 ± 0.36, 1.07 ±
0.28) respectively. Random plasma glucose level was
reduced (5.7 ± 0.5 vs. 6.01 ±
0.43), though not statistically significant (p > 0.05). Vitamin D supplementation is important in
ameliorating dyslipidemia associated with preeclampsia.
Cite this paper
Sonuga, A. A. , Asaolu, M. F. and Sonuga, O. O. (2018). Effects of Vitamin D Supplementation on Lipid Profile and Plasma Glucose of Preeclamptic Women in Ibadan, Nigeria. Open Access Library Journal, 5, e4410. doi: http://dx.doi.org/10.4236/oalib.1104410.
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