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Prediction of the Fragmentation Pathway of Valsartan Protonated Ion

DOI: 10.4236/oalib.1104764, PP. 1-15

Subject Areas: Chemical Engineering & Technology

Keywords: Valsartan, Small Organic Molecules, Fragmentation Pathway, Protonated Ion, Fragmentation, Interpretation

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Abstract

Introduction: A fragmentation pathway of valsartan protonated ion proposed based on rational interpretation workflows. Method: The mass spectral data (MS, MS/MS, and MS3) of valsartan protonated ion, were attained by electrospray positive ionization with flow injection analysis; using liquid chromatography systems hyphenated with hybrid tandem mass spectrometer (Q-trap). Results: The pathway of fragmentation was established using product ions of the protonated ion; elemental composition, molecular structure and mechanism of formation for significant product ions were proposed. A pathway was proposed based on the MS/MS and MS3 spectral data in combination with basic interpretation rules and rational workflows. Conclusion: Workflow used for data interpretation can be useful for writing the fragmentation pathway, a mechanism for the formation of fragments, and can be applied for mass spectral data interpretation of similar small organic molecules.

Cite this paper

Shandilya, D. K. , Israni, R. and Joseph, P. E. (2018). Prediction of the Fragmentation Pathway of Valsartan Protonated Ion. Open Access Library Journal, 5, e4764. doi: http://dx.doi.org/10.4236/oalib.1104764.

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