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Jun 06, 2018Open    AccessArticle

Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*

Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two
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Feb 28, 2018Open    AccessArticle

Ciprofloxacin Hydrochloride Encapsulated into PLGA Nanoparticles for Drug Delivery Application: Fractional Factorial Design

Tajudeen Adebileje, Sikiru Adebileje, P. O. Aye
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. However, encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs) necessitates a defined step to understand the effects and interactions of parameters involved in production process. In pharmaceutics formulations, compared to
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Feb 27, 2018Open    AccessArticle

Study on the Interactions of Two Isomer Selaginellins as Novel Small Molecule Inhibitors Targeting PTP1B by Docking and Molecular Dynamics Simulations

Li Wang, Yi Wang, Dan Meng, Honglei Li
Protein Tyrosine Phosphatase 1B (PTP1B) plays a key role in down-regulation of insulin and leptin signaling pathways. Therefore, development of novel inhibitors of PTP1B has becoming research focus in reducing blood sugar levels for Diabetes Mellitus and Obesity. Hence, we selected two isomer Selaginellins (1 and 2) to explain and analyze the binding mechanism of the two potential inhibitors against the PTP1B by molecule docking a
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Nov 13, 2017Open    AccessArticle

Escherichia coli Resistance to Ciprofloxacin in Acute Uncomplicated Pyelonephritis

Emad Abu Sitta, Nour Aljariri Alhesan, Babikir Kheiri, Sunil Badami, Farah Elounais, Omar Assassa, Maneesh Gaddam, Carlos Rios-Bedoya
Background: Severe acute uncomplicated pyelonephritis is an infection of the kidneys that usually have an ascending route and occur in presumably healthy urinary tract. The most common pathogen involved is E. coli. The Infectious Diseases Society of America (IDSA) has issued an updated guideline in 2010 suggesting IV quinolones to be considered in the initial em
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Nov 09, 2017Open    AccessArticle

Investigation of Contributing Factors to Scombroid Fish Poisoning among Dar es Salaam City Residents in Tanzania

Ngwengwe Bulula, Veronica Mugoyela, Eliangiringa Kaale
Scombroid fish poisoning is a mild to moderate form of food poisoning caused by eating spoiled or bacterial contaminated fish after capture or during subsequent handling and storage. Its symptoms are similar to those of fish allergy though it gives negative results to allergy tests. Because of that, most clinicians misdiagnose scombroid or histamine fish poisoning, and erroneously advise their
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Aug 12, 2016Open    AccessArticle

Qualitative and Quantitative Study on the Suppository of Penyankang

Linli Xia, Xiehe Wang, Congying Wang, Ying Song
Objective: To establish the quality standard for Penyankang Suppository. Method: Thin Layer Identification (TLC) was used for the qualitative identification of Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis and Rhizom Sparganii. High performance liquid chromatography (HPLC) was used to determine the contents of salvianolic acid B and tetrahydropalmatine. Results: Thin Layer Identification (TLC) spots were cle
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Jan 05, 2016Open    AccessArticle

Phytochemical Investigation of Antimicrobial and Antioxidant Activity Leaves Extracts of Corchorus olitorius

Rehab Mobark Osman Mohammed
The leaves extracts of Corchorus olitorius, the family Malvaceae, are commonly called khudra, the plant extensively used in Sudanese traditional medicine. The Sudanese varieties are one of the best in the market, which prompted investigation of leaves extracts. Some chemical analyses of the leaves have been done such as determination of ash content and trace elements (Ca, Fe, Mg, and Na) by atomic absorption spectrometry. The 96% ethanolic, Ethyl acetate and chloroform extracts exh...


Dec 07, 2015Open    AccessArticle

Effect of EGb761 on the Dynamic Changes of Energy Metabolites and Bio-Metal in the Brain Cortex of Gerbil during Focal Cerebral Ischemia

Ming-Cheng Lin
The aim of this study was to evaluate the pharmacological effect of EGb761 on the dynamic alterations of magnesium (Mg) and energy metabolites including glucose and lactate in brain cortex of gerbil during focal cerebral ischemia. A single dose of EGb761 (100 mg/kg, i.p.) was given 30 min prior to cerebral ischemic surgery. Cerebral ischemia was induced by occlusion of the right middle cerebral artery (RMCA) for 180 minutes. Two microdialysis probes were stereotaxically implanted bilaterally int...


Sep 16, 2015Open    AccessArticle

Appraisal of Techniques, Investigation and Analysis of Vitamin (B7) Biotin

Safila Naveed, Fatima Qamar, Syeda Sarah Abbas, Syed Hameez Jawed, Wajiha Raza, Mahera Khan, Bushra Iqbal
Biotin is also called vitamin B7, vitamin B8 or vitamin H. Biotin is a water soluble compound and is colorless in appearance. Overall eight different types of biotin exist but only Biotin-D occurs naturally with its complete vitamin activity. It is mainly synthesized by mold, algae, bacteria, yeast and some plant species. There are different methods used to find the vitamins in nutrients and samples. This article is composed of the comprehensive review of the competitive techniques and various m...


Aug 31, 2015Open    AccessArticle

Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies

Maria Ayub, Amna Islam
NSAIDs are the most widely used drugs globaly and are very famous for their analgesic, anti-in- flammatory and antipyretic actions. The use of NSAIDs in a variety of cancerous conditions is also approved now because of its versatile pharmacologic actions. In this research based study the use of NSAIDs as a chemointerceptive agent in a variety of cancers has been discussed. We aimed to know about the chemopreventive effects of NSAIDs that are a very diverse group of drugs having a lot of pharmaco...


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