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Jun 06, 2018Open    AccessArticle

Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*

Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two

Jan 29, 2015Open    AccessArticle

Trigger Point Infiltrations into the Temporal Muscles of Patients with Fibromyalgia and Headaches: A Randomized, Double-Blinded and Controlled Study

Svetlana Sabatke, Rosana Herminia Scola, Eduardo Paiva, Pedro André Kowacs
Aims: To compare the therapeutic effect of blocking trigger points in temporal muscles by using saline and an anesthetic agent among patients with masticatory myofascial pain syndrome, fibromyalgia and headaches and with non-infiltrated controls. Methods: One hundred women, aged 23 to 70 years old, were initially triaged. The seventy patients who experienced at least one trigger point in the temporal muscles were randomly divided into three groups, as follows: saline infiltration, anesthetic inf...

Nov 28, 2014Open    AccessArticle

Chronic Headache with Unusual Episode: A Case of Cerebral Venous Sinus and Extracranial Venous Thrombosis in Antiphospholipid Syndrome

Chaw Su Naing, Lim Wan Tin, Slapak Gabrielle, Balakrishnan Tharmmambal

Cerebral venous sinus thrombosis (CVST) with concomitant extracranial venous thrombosis is not a common clinicopathological entity. Extensive venous thrombosis involving head and neck affects young adult and female gender with isolated CVST contributing about 75% of the cases. The clinical features of CVST are nonspecific and can mimic various conditions. The neuroimaging investigation especially CT, MR angiography and venography are used to establish the diagnos


Aug 14, 2014Open    AccessArticle

A Search for Factors that Predict the Efficacy of Viscosupplementation in Knee Osteoarthritis

R. Michelle Koolaee, H. Ralph Schumacher, Michael Shoemaker, Sarah Mooar, Sally Pullman-Mooar

Objective: Previous research demonstrates inconsistent effects of hyaluronate (HA) viscosupplementation on patients with knee osteoarthritis (OA). The purpose of this study was to evaluate factors that predict clinical response to a single intra-articular injection of Hylan GF-20. Methods: This was an observational study of 55 patients with knee OA, scheduled to receive intra-articular injections of Hylan GF-20. These patients met the institution’s guide