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Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.

Jun 26, 2018Open    AccessArticle

The Origin of Life Discovered: ΣRNA

Muying Zhou
Since 1992, scientific knowledge has been enough to determine the origin of life: “life originated through RNA”. The truth is that current life world on Earth is just an RNA world, since the protein is created by RNA, then DNA as life’s database is created by RNA along with reverse transcriptase (a protein of RNA making). The two life series on the planet originated through two RNA groups (named ΣRNA ): IΣRNA and IIΣRNA . IΣRNA

Jan 30, 2018Open    AccessArticle

Characterization of Chitosan Membranes Crosslinked by Sulfuric Acid

Thiago B. Fideles, José Luis Santos, Helena Tomás, Glória T. F. S. Furtado, Daniel B. Lima, Silvia M. P. Borges, Marcus V. L. Fook
Development of novel biomaterials and its practical application have been the subject of much research in the field of scaffolds for tissue engineering, providing the success of producing scaffolds biomaterials that facilitate tissue growth and provide structure support for cells. Due to its biocompatibility and biodegradability, chitosan has been the focus of several researches in recent years to be applied in the

May 05, 2017Open    AccessArticle

Electronmicroscopic Study of Nanolike Bacteria

Karlen Hovnanyan, Margarita Hovnanyan, Armen Trchounian
Nanobacteria individual cases under the name of suggesting the bacteria mycoplasma and L-transformed forms of bacteria that imitate their size are nanobacteria that a separate systematic units remains controversial; the introduction of new high-resolution analytical microscopy techniques of prokaryote and eukaryote has revealed new structures in the structures of bacteria, which are the target of physical, chemical and biologicall

Mar 14, 2017Open    AccessArticle

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum

Gao-De Li
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be closely li

Nov 07, 2016Open    AccessArticle

Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Antoine Laudat, Laurence Burc-Struxiano
Objective: Here we compared the results of a prospective study systematically screening for antisperm antibodies in a cohort of subfertile males to the results of a previous retrospective study in equally subfertile patients where screening for antisperm antibodies was performed solely if semen presented spontaneous agglutinates of sperm. Methods: The prospective study was conducted on 317 semen analyses between 1 September 2014 a

Aug 17, 2016Open    AccessArticle

Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress

Gao-De Li
This paper proposes that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome “self-injury”) that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely repaired later. The released ssDNA fragments may play some role in the regulation of cell cycle progression. Taken together, genoau

Jul 26, 2016Open    AccessArticle

Targeted Mutagenesis of Beta-Lactoglobulin Gene in Caprine Fetal Fibroblasts by Context-Dependent Assembly Zinc-Finger Nucleases

Yuguo Yuan, Yong Cheng, Jinyu Wang, Qiuling Peng
Targeted mutagenesis by zinc-finger nucleases (ZFNs) can be used to generate knock-out mammalian cell lines with high efficiency. A number of different methods have been developed for the design and assembly of gene-specific ZFNs, making them easily accessible to researchers. In this study, we used ZFNs assembled through the CoDA (context-dependent assembly) platforms to generate mutant caprine fetal fibroblasts cells for the BLG

Jun 17, 2016Open    AccessArticle

A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells: Endonuclease Dependent Transcript Cutout

Gao-De Li
We previously proposed the existence of DNA to DNA transcription in eukaryotic cells, but the mechanism by which single-stranded DNA (ssDNA) transcript is produced and released from the genome remains unknown. We once speculated that the mechanism of DNA to DNA transcription might be similar to that of DNA to RNA transcription, but now we propose that endonuclease dependent transcript cutout may be a possible mechanism of DNA to D

Jun 13, 2016Open    AccessArticle

Applications of Nanotechnology in Reconstructive Surgery

Timothy Varghese
The objective of this review was to critically present and evaluate recent investigations into nanotechnology and it’s applications in reconstructive surgery. In addition, this review aims to looks at a plethora of applications with nanotechnology in the subject area of reconstructive surgery. The Medline and PubMed databases were searched for clinical trial and case report publications dealing with reconstructive surgeries involv