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Feb 01, 2019Open AccessArticle
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented. ...
Jun 26, 2018Open AccessArticle
Since 1992, scientific knowledge has been enough to determine the origin of life: “life originated through RNA”. The truth is that current life world on Earth is just an RNA world, since the protein is created by RNA, then DNA as life’s database is created by RNA along with reverse transcriptase (a protein of RNA making). The two life series on the planet originated through two RNA groups (named ΣRNA ): IΣRNA and IIΣRNA . IΣRNA ...
Jan 30, 2018Open AccessArticle
Development of novel biomaterials and its practical
application have been the subject of much research in the field of scaffolds
for tissue engineering, providing the success of producing scaffolds
biomaterials that facilitate tissue growth and provide structure support for
cells. Due to its biocompatibility and biodegradability, chitosan has been the
focus of several researches in recent years to be applied in the ...
May 05, 2017Open AccessArticle
Nanobacteria individual cases under the name of
suggesting the bacteria mycoplasma and L-transformed forms of bacteria that imitate
their size are nanobacteria that a separate
systematic units remains controversial; the introduction of new high-resolution analytical microscopy techniques
of prokaryote and eukaryote has revealed new
structures in the structures of bacteria, which are the target of physical,
chemical and biologicall ...
Mar 14, 2017Open AccessArticle
As
a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century.
However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that
the mechanism of CQ action and resistance
might be closely li ...
Nov 07, 2016Open AccessArticle
Objective: Here we compared the results of a
prospective study systematically screening for antisperm antibodies in a cohort
of subfertile males to the results of a previous retrospective study in equally
subfertile patients where screening for antisperm antibodies was performed
solely if semen presented spontaneous agglutinates of sperm. Methods: The prospective
study was conducted on 317 semen analyses between 1 September 2014 a ...
Aug 17, 2016Open AccessArticle
This paper proposes that eukaryotic cells, under severe genotoxic stress,
can commit genoautotomy (genome “self-injury”) that involves cutting and
releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and
leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely
repaired later. The released ssDNA fragments may play some role in the
regulation of cell cycle progression. Taken together, genoau ...
Jul 26, 2016Open AccessArticle
Targeted mutagenesis by
zinc-finger nucleases (ZFNs) can be used to generate knock-out mammalian cell
lines with high efficiency. A number of different methods have been developed
for the design and assembly of gene-specific ZFNs, making them easily accessible
to researchers. In this study, we used ZFNs assembled through the CoDA
(context-dependent assembly) platforms to generate mutant caprine fetal fibroblasts
cells for the BLG ...
Jun 17, 2016Open AccessArticle
We previously proposed the existence of DNA to DNA transcription in
eukaryotic cells, but the mechanism by which single-stranded DNA (ssDNA)
transcript is produced and released from the genome remains unknown. We once
speculated that the mechanism of DNA to DNA transcription might be similar to
that of DNA to RNA transcription, but now we propose that endonuclease dependent
transcript cutout may be a possible mechanism of DNA to D ...
Jun 13, 2016Open AccessArticle
The objective of this review was to critically present and evaluate recent
investigations into nanotechnology and it’s applications in reconstructive
surgery. In addition, this review aims to looks at a plethora of applications
with nanotechnology in the subject area of reconstructive surgery. The Medline
and PubMed databases were searched for clinical trial and case report
publications dealing with reconstructive
surgeries involv ...
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