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Jun 07, 2018Open    AccessArticle

The Law of Self-Replication and the Birth of Life Science

Muying Zhou
The understanding of the unique replication facts of living things helps us to discover the basic law of the life world: the law of self-replication. This law re-veals the root causes of life arising and lays the foundation stone for life sci-ence. From now on, what is a living thing, what does life mean? There has been a standard (the definition).


May 29, 2018Open    AccessArticle

The Answer to the “First Question” in Genetics: The Hereditary Material

Muying Zhou
The basis of genetics should be the hereditary material which should be able to produce the individual. DNA (Genes) is ever regarded as the producer of the individual. However, DNA being lack of producing force can not produce the individual. So, this paper’s task is to look for another element, producing force, which along with genes (DNA) forms the hereditary material. And finally the paper
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Mar 15, 2018Open    AccessArticle

Detection of Horizontal Transfer of Housekeeping and Hydrocarbons Catabolism Genes in Bacterial Genus with Potential to Application in Bioremediation Process

Edmo Montes Rodrigues, Fernanda de Souza Freitas, Tatiane de Paula Siqueira
In silico analysis can be useful to infer about the horizontal gene transfer (HGT) as well as to deduce about the evolutionary relations of catabolic genes. In this study, we performed the analysis of two housekeeping genes (fabD and rpoD) and two catabolic gene
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Feb 27, 2018Open    AccessArticle

Do You Realize Two Basic Questions in Genetics?

Muying Zhou
There are two basic questions in genetics. The “first question” inquires about the germplasm that is capable of producing an individual. It asks “Who produces the individual?” Preformation, Darwin’s Pangenesis, and Weisman’s Germ-plasm theories are all attempts to answer the “first question”. The “second question” usually arises in sexually reproducing species. Because there are two parents (dad and mom) that form the producer (ge
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Oct 18, 2017Open    AccessArticle

Metabolic Syndrome among Ischaemic Stroke Patients in Ghana: The Possible Role of Renin and Aldosterone

Francis Agyemang Yeboah, Bernard Nkum, Bright Amankwaa, Benjamin Ackon Eghan Jr., Emmanuel Acheampong, Paul Nsiah, Perditer Okyere, Lawrence Owusu, Emmanuella Batu Nsenba, Enoch Odame Anto
Background: Both metabolic syndrome (MetSyn) and the Renin Angiotensin Aldosterone System (RAAS) are predictors of adverse outcomes in stroke patients. This study aimed at evaluating the association between RAAS and MetSyn among ischaemic stroke subjects in a tertiary hospital of Ghana from September 2015 to June 2016. Methodology: The study purposively recruited 252 Ghanaians comprising 132 ischaemic stroke patients and 120 appar
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Mar 14, 2017Open    AccessArticle

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum

Gao-De Li
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be closely li
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Feb 15, 2017Open    AccessArticle

UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa

Erick Ntambwe Kamangu, Jérémie K. Mbinze, Arnold M. Mingu, Jacquie B. Bolavie, Georges Lelo Mvumbi, Richard Lunganza Kalala, Gauthier Kahunu Mesia, Mariano Lusakibanza, Jean Mavar, Roland D. Marini
Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus allow the immune system to recover. In 2001, the program to fight against HIV/AIDS United Nations (UNAIDS) and its partners has decided to strengthen the pharmaceutical channel and improve access to good quality
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Feb 09, 2017Open    AccessArticle

Methods for Non-Destructively Separating or Reannealing the Strands of Circular Duplex DNA Chromosomes

Ken Biegeleisen
Although it is not widely-known, the strands of circular duplex plasmid and viral chromosomes have been non-destructively separated, and the separated strands have been reconstituted to yield a new duplex structure with all the properties of the native chromosome restored. This suggests a paranemic structure for the DNA, that is, a structure whose strands are no
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Oct 26, 2016Open    AccessArticle

The Probable Structure of “Form IV” (Alkali-Denatured Circular DNA)

Ken Biegeleisen
A detailed molecular model for alkali-denatured duplex circular DNA (“Form IV”) is proposed. The illustrative biological example used is the replicative form of fx174, a 5 kb duplex circular chromosome. The model explains all of Form IV’s known and peculiar features. In a sedimentation coefficient vs. pH titration, Form IV begins to appear at pH 12.3, at which point it can be persuasively argued that no further supertwists can be
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Aug 17, 2016Open    AccessArticle

Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress

Gao-De Li
This paper proposes that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome “self-injury”) that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely repaired later. The released ssDNA fragments may play some role in the regulation of cell cycle progression. Taken together, genoau
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