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Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco

DOI: 10.1186/1746-1596-7-170

Keywords: Breast cancer, Molecular classification, Luminal B subtype, Staging, Antibodies, Immunohistochemistry

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Abstract:

We reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied.The average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%).This study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment.http://www.diagnosticpathology.diagnomx.eu/vs/1675272504826544 webciteBreast cancer is a heterogeneous disease such that they may have different prognoses and respond to therapy differently despite similarities in histological types, grade and stage. Based on the presence or absence of expression of the estrogen receptor (ER), breast cancer is divided in two groups: ER+ and ER-. Genetic expression profile has identified two subtypes of the ER+ tumors: luminal A and luminal B. ER- tumors also include two subtypes, the HER2+ and the basal type. These subtypes differ in their biology and both demonstrate short disease-free periods after treatment and poorer outcome. In Morocco, it’s the first cancer in women and is currently a major public health problem. The molecular classification in breast carcinomas is now based upon gene expression analysis using DNA microarrays and allows to identify at least five groups: luminal A, luminal B, HER2-overexpressing, basal-like and normal breast-like [1-3]. However, large-scale subtyping using gene expression profiling from formalin-fixed, paraffin-embedded samples is not currently feasible and remains very expensive. Therefore, immunohistochemical markers have been used as surrogates tools for

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