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Microcystic Variant of Urothelial Carcinoma

DOI: 10.1155/2013/654751

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Abstract:

Background. Microcystic variant of urothelial carcinoma is one of the new variants of urothelial carcinoma that was added to the WHO classification in 2004. Aims. To review the literature on microcystic variant of urothelial carcinoma. Methods. Various internet search engines were used to identify reported cases of the tumour. Results. Microscopic features of the tumour include: (i) Conspicuous intracellular and intercellular lumina/microcysts encompassed by malignant urothelial or squamous cells. (ii) The lumina are usually empty; may contain granular eosinophilic debris, mucin, or necrotic cells. (iii) The cysts may be variable in size; round, or oval, up to 2?mm; lined by urothelium which are either flattened cells or low columnar cells however, they do not contain colonic epithelium or goblet cells; are infiltrative; invade the muscularis propria; mimic cystitis cystica and cystitis glandularis; occasionally exhibit neuroendocrine differentiation. (iv) Elongated and irregular branching spaces are usually seen. About 17 cases of the tumour have been reported with only 2 patients who have survived. The tumour tends to be of high-grade and high-stage. There is no consensus opinion on the best option of treatment of the tumour. Conclusions. It would prove difficult at the moment to be dogmatic regarding its prognosis but it is a highly aggressive tumour. New cases of the tumour should be reported in order to document its biological behaviour. 1. Introduction Since microcystic variant of urothelial carcinoma was added to the WHO classification, very few cases have been reported in the literature, and in view of this most practitioners would be unfamiliar with the biological behaviour of this rare type of tumour. The ensuing paper contains literature review of microcystic variant of urothelial carcinoma. 2. Methods Various internet search engines including Google, Google Scholar, PubMed, Educus. and UpToDate were used to identify the literature including case reports, case series, and review papers on microcystic variant of urothelial carcinoma for the review of the literature on microcystic variant of urothelial carcinoma. The key words that were used included microcystic variant of urothelial carcinoma and microcystic transitional cell carcinoma. In all 17 documentations were found which were relevant to the aetiology, presentation, diagnosis, management, and outcome of microcystic variant of urothelial carcinoma. 3. Literature Review 3.1. Overview 3.1.1. Definition and Terminology Microcystic variant of urothelial carcinoma is one of the variants of

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