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A Modified Limberg Flap versus Z Plasty Flap Technique in Management of Recurrent Pilonidal Disease: A Comparative Prospective Study  [PDF]
Asmaa Gaber R., Mohamed Yousef A., Mohamed Abdel Shafy Mohamed, Abd-El-Aal A. Saleem, Hassan A. Abdallah, Hamdy M. Husein
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104715
Abstract:
Background: There are controversies about the etiology and management of recurrent pilonidal sinus. The numbers of techniques are testament in treating pilonidal sinus (PNS) and no single procedure is superior in all aspects. Aim of the study: The aim of this study was to compare two operative procedures (modified Limberg flap versus Z plasty flap) in management of recurrent pilonidal sinus, regarding their complications including recurrences of the disease, morbidity, hospital stay, day off work and postoperative complications. Patients and methods: This is comparative prospective study between modified Limberg flap and Z plasty flap in treatment of recurrent pilonidal sinus. 30 patients were divided into 2 groups: Group (1) treated with modified Limberg flap and group (2) treated with Z plasty, and we followed up the patients in both groups for postoperative complications, hospital stay, day off work, recurrences, patients satisfactions. Results: Operative time, hospital stay duration, complete wound healing was longer in group (2) Z plasty group. Mobilization was early in MLF group than Z plasty group (1 day versus 2 days). Time to return to work, it was 14 (12 - 16) days in MLF groups and 18 (15 - 22) in Z plasty group (p < 0.001). Infection occurred only in one in MLF group (1) and 2 patients in Z plasty group (2). The mean time for complete healing of the wound after Modified Limberg flap group (1) was 16 ± 4.2 days while in Z plasty group (2) it was 22 ± 6.8 days. Satisfaction score was better in MLF group (1). Recurrence hadn’t occurred in any of the patients included in this study during the follow-up period. Conclusion: Both of modified Limberg flap and Z-plasty technique are used to cause flattening of the natal cleft, thus reducing local recurrence rates. So, we recommend use of flap technique for recurrent pilonidal sinus patients; modified Limberg transposition flap is better than Z plasty flap, because of the less hospital stay time, early return to work, and cosmetically more accepted as it has less postoperative complications. Also Z plasty flap has a major limitation as it is difficult to apply if there is a wide defect in the horizontal axis.
Nephroprotective Effect of Nigella Sativa and Matricaria Chamomilla in Cisplatin Induced Renal Injury—Supportive Treatments in Cisplatin Nephrotoxicity  [PDF]
Ragaa H. M Salama, Nahed A Abd-El-Hameed, Sary KH Abd-El-Ghaffar, Zaghloul T. Mohammed, Nagwa M. A Ghandour
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.23031
Abstract: Nigella sativa and Matricaria chamomilla are extensively consumed as tea or tonic. Despite their widespread use as a home remedy, relatively few trials evaluated their benefits in nephroprotection. Hence, this study evaluates the nephroprotective effects of supportive treatments (N. sativa, M. chamomilla and vitamin E) in cisplatin nephrotoxicity rat model. Eighty rats divided into 10 groups, of 8 animals each. The first group (G1) injected with saline intra-pretoneal (i.p). G2 injected with 5 mg/kg cisplatin i.p on zero day of experiment and repeated 4 times, with 5 days free interval. G3-G10 received daily supportive treatments, started 5 days before the experiment (–5day). Concomitantly G4, G6, G8 and G10 injected with 5 mg/kg cisplatin i.p like G2. On day sixteen, animal scarified, serum and/or kidney tissue were used to determine kidney function tests (serum urea, creatinine, NAG, β-gal), oxidative stress indices (NO, LPO), antioxidant activities (SOD), sulphur compounds (GGT, GSH, total thiols ), apoptotic indices (cathepsin D, DNA fragmentation), two minerals (Ca2+ and zn2+). Cisplatin caused marked elevation in serum GGT that reduced signifi-cantly in group received M. chamomilla with cisplatin (P < 0.001). There is a correlation between GGT and NAG in cisplatin group (r = 0.731 p < 0.05) that may suggest one of possible mechanisms of renal injury by cisplatin. M. chamomilla followed by N. sativa and vitamin E improved the biochemical and pathological renal injury, as determined by increasing the body weight, normalizing the kidney functions, decreasing the oxidative stress markers, improving the apoptotic markers, minimizing the pathological changes. Hence, N. sativa and M. chamomilla will be a promising nephroprotective agents for reducing cisplatin nephrotoxicity, most probably, by antioxidants effects and inhibition GGT production, respectively.
New Edge Detection Technique based on the Shannon Entropy in Gray Level Images
Mohamed A. El-Sayed,,Tarek Abd-El Hafeez
International Journal on Computer Science and Engineering , 2011,
Abstract: Edge detection is an important field in image processing. Edges characterize object boundaries and are therefore useful for segmentation, registration, feature extraction, and identification of objects in a scene. In this paper, an approach utilizing an improvement of Baljit and Amar method which uses Shannon entropy otherthan the evaluation of derivates of the image in detecting edges in gray level images has been proposed. The proposed method can reduce the CPU time required for the edge detection process and the quality of the edge detector of the output images is robust. A standard test images, the real-world and synthetic images are used to compare the results of the proposed edge detector with the Baljit and Amar edge detector method. In order to validate the results, the run time of the proposed method and the pervious method are presented. It has been observed that the proposed edge detector works effectively for different gray scale digital images. The performance evaluation of the proposed technique in terms of the measured CPU time and the quality of edge detector method are presented. Experimental results demonstrate that the proposed method achieve better result than the relevant classic method.
New Edge Detection Technique based on the Shannon Entropy in Gray Level Images
Mohamed A. El-Sayed,Tarek Abd-El Hafeez
Computer Science , 2012,
Abstract: Edge detection is an important field in image processing. Edges characterize object boundaries and are therefore useful for segmentation, registration, feature extraction, and identification of objects in a scene. In this paper, an approach utilizing an improvement of Baljit and Amar method which uses Shannon entropy other than the evaluation of derivatives of the image in detecting edges in gray level images has been proposed. The proposed method can reduce the CPU time required for the edge detection process and the quality of the edge detector of the output images is robust. A standard test images, the real-world and synthetic images are used to compare the results of the proposed edge detector with the Baljit and Amar edge detector method. In order to validate the results, the run time of the proposed method and the pervious method are presented. It has been observed that the proposed edge detector works effectively for different gray scale digital images. The performance evaluation of the proposed technique in terms of the measured CPU time and the quality of edge detector method are presented. Experimental results demonstrate that the proposed method achieve better result than the relevant classic method.
Low Phenylalanine Egyptian Shamy Bread
Attia A. Yaseen, Abd-El-Hafeez A. Shouk
Polish Journal of Food and Nutrition Sciences , 2011, DOI: 10.2478/v10222-011-0029-1
Abstract: Four formulas were prepared for production of low phenylalanine Egyptian shamy bread suitable for phenylketonuria (PKU) patients. The formulas were based on partial replacement of first break wheat flour (low protein flour) with different levels of corn starch. Pectin and carboxymethylcellulose (CMC) were used as a texture modifier and to improve staling rate of bread. Shamy bread made of 100% first break wheat flour was also prepared for comparison. Chemical composition, amino acids content, dough characteristics, baking test, sensory evaluation and staling rate of bread were investigated. A remarkable reduction of protein, consequently, phenylalanine of bread was detected. Phenylalanine content of formula "D", which contained 66 g of corn starch, 30 g of first break wheat flour, 2 g of pectin and 2 g of CMC, was reduced by 62% compared with the control. The rheological properties of the dough were affected by starch and hydrocolloids incorporation. Sensory characteristics of bread indicated that all formulas were acceptable, but formula "D" seems to be superior for PKU patients.
X-ray Shielding Ability and Electrophysical Characteristics of Rubber Vulcanizates: Effect of State-of-Mix
M. Madani and A.I. Abd-El Hafez
Particle Physics Insights , 2012, DOI: 10.4137/PPI.S0
Abstract: Rubber composite materials were prepared using styrene-butadiene-rubber as matrices and incorporating with carbon black and PbO2 for X-ray shielding. The pure gum SBR was firstly masticated with different mastication times before mixing. It was found that the mastication time strongly affected the microstructure of the prepared composites and in turn, the degree of cross-link density. The mastication time greatly improves the dispersion level of the used fillers. The effect of mastication time on the conductivity, currentvoltage characteristics and TSDC of composites was investigated. The X-ray shielding ability of all composites apparently increases with the increase in mastication time. X-ray shielding ability of the prepared composites was also studied at different applied voltage and current of X-ray machine.
Pro-inflammatory cytokine; tumor-necrosis factor-alpha (TNF-α) inhibits astrocytic support of neuronal survival and neurites outgrowth  [PDF]
Ebtesam M. Abd-El-Basse
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.48A2010
Abstract:

Reactive astrogliosis has been implicated in the failure of axonal regeneration in adult mammalian Central Nervous System (CNS). It is our hypothesis that inflammatory cytokines act upon astrocytes to alter their biochemical and physical properties, which may in turn be responsible for the failure of neuronal regeneration. We have therefore examined the effect of tumor-necrosis factor-alpha (TNF-α) on the ability of astrocytes to support the survival of the cortical neurons and the growth of the neurites. Mouse astrocytes and cortical neuronal cultures were prepared. It was observed that when neurons were cultured in absence of astrocytes only a few of them grew and survived only for 5-6 days. These neurons had small cell bodies and few, short neurites. However, when the same numbers of neurons were cultured on the top of astrocytes, more neurons grew and survived up to 16-18 days. They had bigger cell bodies and many long branched neurites that formed anestamosing networks. The neurons then coalesced and the neurites formed thick bundles. When the same numbers of neurons were grown on the top of astrocytes pre-treated with TNF-α, few neurons survived up to 13 days. The neurites of the survived neurons were shorter than neurites of neurons grown on normal astrocytes and did not form bundles. In addition, TNF-α stimulated the expression of glial fibrillary acidic protein (GFAP) by astrocytes. These results support that the pro-inflammatory cytokine, TNF-α modulates the gliosis and that the astrocytic cell supports neuronal survival and neurite outgrowth.

Rasch Rating Scale Analysis of the Arabic Version of the Physical Activity Self-Efficacy Scale for Adolescents: A Social Cognitive Perspective  [PDF]
Sabry M. Abd-El-Fattah
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.616213
Abstract: This study uses the Rasch rating scale analysis within the framework of the social cognitive theory to examine four psychometric properties of the Arabic version of the Physical Activity Self-efficacy Scale for Adolescents (PASESA-Av): 1) item technical quality to evidence content validity; 2) unidimensionality structure to evidence structural validity; 3) rating scale functioning to evidence substantive validity; and 4) person and item separation and reliability. The analyses showed that the PASESA-Av items represented the physical activity self-efficacy trait adequately. The PASESA-Av demonstrated good fit to the Rasch model and formed a unidimensional structure. The PASESA-Av response categories advanced monotonically. The PASESA-Av demonstrated satisfactory person and item separation and reliability.
Effect of Interleukin-1Beta (IL-1β) on the Cortical Neurons Survival and Neurites Outgrowth  [PDF]
Ebtesam M. Abd-El-Basset
Advances in Bioscience and Biotechnology (ABB) , 2016, DOI: 10.4236/abb.2016.71004
Abstract: Insults to the brain are known to cause a myriad of downstream effects, including the release of cytokines by astrocytes and resultant reactive gliosis. The author has examined effect of cytokine IL-1β on the survival of cortical neurons using mouse astrocyte-neuron co-culture. Five groups were used. These were neurons alone (Group 1), neurons with added IL-1β (Group 2), neurons co-cultured with astrocytes (Group 3), neurons co-cultured with astrocytes that was pre-treated with IL-1β before co-culture (Group 4) and neurons co-cultured with astrocytes and IL-1β added (post-treated) (Group 5). In Group 1 only a few neurons grew and survived only for 5-6 days. In Group 2, it was observed that more neurons survived up to 11 days. Moreover, in Group 3, more neurons grew and survived up to 16-18 days. They had large cell bodies and many long neurites that formed anastomosing networks. In Group 4, few neurons survived up to 13 days, whereas in Group 5, the growth of neurons were affected but to a much lesser extent than Group 4 and survived up to 15 days. In addition, it was found that IL-1β stimulated the expression of glial fibrillary acidic protein (GFAP) by astrocytes. This study indicates that IL-1β affects the survival of cortical neurons and modulates the astrocytic support to neuronal survival and neurites outgrowth by acting directly on the astrocytes.
Relationship between peripheral arterial disease, carotid intima-media thickness and C-reactive protein in elderly diabetic patients  [PDF]
Moatassem Salah Amer, Samia Ahmed Abdul-Rahman, Wafaa Mostafa Abd-El Gawad, Ibrahim Ahmad Abdel Aal, Ahmad Abdel Khalek Abdel Razek Mohamed, Wessam El-Huseiny Moustafa Abdel Wahab
Advances in Aging Research (AAR) , 2013, DOI: 10.4236/aar.2013.24017
Abstract: Purpose: To study the association between carotid intima media thickness (CIMT) and high sensitivity CRP (hs-CRP) level as markers for PAD in elderly patients with DM. Subjects: A case-control study on 90 participants aged 60 years and older divided into 60 cases (30 patients with DM alone and 30 patients with DM and comorbidities) and 30 healthy controls. All were assessed by measuring CIMT, ankle brachial index (AB), and markers for cardiovascular disease such as high-sensitivity CRP (hs-CRP), total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL). Results: hs-CRP levels showed statistically significant difference being highest among patients with DM and comorbidities and lowest among controls (P < 0.001). Also, symptoms of PAD were significantly higher among cases than controls. ABI was able to detect PAD in many asymptomatic patients. Color changes were present in only 43.30% (n = 26) of positive PAD cases while delayed wound healing, claudication pain, rest pain, cold extremities, and trophic changes were present in 23.30% (n = 14), 16.71% (n = 10), 16.71% (n = 10), 45.00% (n = 27), and 21.7% (n = 13). Using logistic regression analysis revealed that DM, CIMT, and hs-CRP were independent predictors for PAD (OR = 4.194, 7.236, 1.003; P value = 0.044, 0.25, 0.031) after adjustment of other coronary risk factors such as sex, smoking, hypertension, TC, and TG. Conclusion: Diabetic elderly have higher prevalence of asymptomatic PAD thannon-diabetics using solely ABI. DM, CIMT, and hs-CRP are independent predictors for the occurrence of PAD. Hs-CRP levels are highest among diabetics with comorbidities.
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