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Clinicopathological Pattern of Gastric Cancer of Yemeni Patients in Ibb Governorate  [PDF]
Abdulgafoor Kassim, Mohammed Al-Qubaty, Fayed Al-Yousofy, Ramea Alathwary, Sana Ameen
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104415
Abstract:
Objectives: To study the clinicopathological pattern of gastric cancer in-cluding the location of the tumor in the stomach and to compare our results with other studies. Design: Prospective study of patients confirmed with gastric malignancy during the period from July 2016 to July 2017. Setting: Specialized center of gastrointestinal and liver diseases in Ibb city, Yemen. Subjects: All patients with histopathological confirmation of gastric malig-nancy. Results: During the study period, we had 69 patients with gastric cancer; among them 48 were males and 21 were females, with male: Female ratio is 2.2:1. The age ranged between 35 years and 90 years and the mean age was 65.87 ± 12.79 years. Most of the patients presented with epigastric pain (87%), weight loss (72.5%), pallor (65.2%), dysphagia (47.8%), vomiting (42%), palpable epigastric mass (20.3%) and hematemesis/melena (18.8%). The cardiofundal location was encountered in 33 cases (47.8% ), 22 (45.8%) males and 11 (52.4%) females, the corpus location in 24 cases (26%), 20 (41.7%) males and 4 (19%) females, the antral location in 8 cases (11.6%), 4 (8.3%) males and 4 (19%) females and the whole stomach in 4 cases (5.8%), 2 (4.2%) males and 2 (9.5%) females. Adenocarcinoma constituted about 94.2%, of which the intestinal type was 87.5% and the diffuse type was 12.5%. The non-epithelial tumor was encounter 4.3%, of which 2.9% were lymphoma and 1.4% were GIST. Conclusion: In our studied patients, proximally located gastric cancer was the most common in both sexes.
Pre-existing diabetes mellitus and adverse pregnancy outcomes
Hayfaa A Wahabi, Samia A Esmaeil, Amel Fayed, Ghadeer Al-Shaikh, Rasmieh A Alzeidan
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-496
Abstract: This is a retrospective cohort study for women who delivered in King Khalid University Hospital (KKUH) during the period of January 1st to the 31st of December 2008. The pregnancy outcomes of the women with PDM were compared to the outcomes of all non-diabetic women who delivered during the same study period.A total of 3157 deliveries met the inclusion criteria. Out of the study population 116 (3.7%) women had PDM. There were 66 (57%) women with type 1 diabetes mellitus (T1DM) and 50 (43%) women with type 2 diabetes mellitus (T2DM). Compared to non-diabetic women those with PDM were significantly older, of higher parity, and they had more previous miscarriages. Women with PDM were more likely to be delivered by emergency cesarean section (C/S), OR 2.67, 95% confidence intervals (CI) (1.63-4.32), P < 0.001, or elective C/S, OR 6.73, 95% CI (3.99-11.31), P < 0.001. The neonates of the mothers with PDM were significantly heavier, P < 0.001; and more frequently macrosomic; OR 3.97, 95% CI (2.03-7.65), P = 0.002. They more frequently have APGAR scores <7 in 5?minutes, OR 2.61, 95% CI (0.89-7.05), P 0.057 and more likely to be delivered at <37 gestation weeks, OR 2.24, 95% CI (1.37- 3.67), P 0.003. The stillbirth rate was 2.6 times more among the women with PDM; however the difference did not reach statistical significance, P 0.084.PDM is associated with increased risk for C/S delivery, macrosomia, stillbirth, preterm delivery and low APGAR scores at 5?min.It is estimated that by the year 2030 more than 360 million people will have diabetes mellitus (DM) [1] and as the burden of the disease increases the management of pregnancies complicated by DM will be part of the daily obstetric practice in many regions of the world. Studies investigating the influence of ethnicity on the outcome of pregnancies complicated by pre-existing diabetes mellitus (PDM) reported variation in the outcome with different ethnic groups with worse outcome for Asian [2] and Afro-Caribbean mothers c
Healthy Multifunctional Spectra of Milk Glycoproteins and Their Fragments - a Review Article
Atef E. Fayed
Polish Journal of Food and Nutrition Sciences , 2012, DOI: 10.2478/v10222-012-0053-9
Abstract: The functionalities of glycoprotein lactoferrin (LF) and glycomacropeptide (GMP) were discussed. LF is considered a multifunctional protein. Its absorption in the bowel; immune response; antioxidant, anti-carcinogenic and anti-inflammatory properties; and protection against microbial infection, were the most widely studied functions to date. Besides, promotion of balanced intestinal flora by preventing growth of harmful bacteria and stimulating bifidus, LF helps to secure a correct balance of the intestinal flora. Although, most of the proposed biological activities of LF are related to the binding of iron, the non-iron related functions have been described as well, such as regulation of iron metabolism, prevention of oxidation and control of cell or tissues damage (result of aging). Likewise, GMP, which is a carbohydrate-containing peptide formed from chymosin or pepsin digestion of κ-casein, exhibits several useful biological activities, including binding of cholera toxin and E. coli enterotoxins, inhibition of bacterial and viral adhesions, suppression of gastric secretions, promotion of bifidobacterial growth, and modulation of immune responses. GMP contains no aromatic amino acids and is therefore used for phenylketonuria (PKU) suffering patients. The carbohydratic parts bound to such glycoprotein or glycopeptide, may act as prebiotics in the intestine and colon.
Synthesis of New Macrocyclic Polyamides as Antimicrobial Agent Candidates
Osama I. Abd El-Salam,Mohamed A. Al-Omar,Ahmed A. Fayed,Eman M. Flefel,Abd El-Galil E. Amr
Molecules , 2012, DOI: 10.3390/molecules171214510
Abstract: A series of macrocyclic imides and Schiff-bases have been prepared via the cyclocondensation of pyridine-2,6-dicarbonyl dichloride (1) with L-ornithine methyl ester to give the corresponding macrocyclic bisester 2. Treatment of 2 with hydrazine hydrate gave macrocyclic bisacid hydrazide 3, which was used as starting material. Condensation of bishydrazide 3 with diacid anhydrides or aromatic aldehydes in refluxing acetic acid or ethanol gave the corresponding macrocyclic bisimides 4, 5a,b and macrocyclic bis- hydrazones 6a–j, respectively. The structure assignments of the new compounds were based on chemical and spectroscopic evidence. The antimicrobial screening showed that many of these newly synthesized compounds have good antimicrobial activities, comparable to ampicillin and ketaconazole used as reference drugs.
Rapid Urease Test and Faecal Antigen Detection for Rapid Diagnosis of Helicobacter pylori Infection in Dyspepsia  [PDF]
Hasan Sedeek Mahmoud, Hanan M. Fayed, Ghada S. Osman
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.61002
Abstract: Background: Helicobacter pylori (H. pylori) is considered as one of the most prevalent gastric infections which cause chronic gastritis and predispose to cancer stomach. So, diagnosis and eradication should be rapid to decrease the risk of gastric cancer. Aim of the study: To evaluate the role of rapid urease test (RUT) and faecal antigen test (FAT) added to serological test for rapid diagnosis of active H. pylori infection. Patients and methods: 270 patients with dyspepsia and positive serology for H. pylori infection were included. Two antral and two corporal gastric biopsies were taken for RUT and Histopathological examination. Fresh stool samples were obtained from all patients for FAT. Results: The mean age of the studied patients was 45 ± 25. H. pylori infection was found in 256 (94.8%) of the included patients: 236 (92.18%) with positive all tests, 5 (1.95%) with positive both RUT and FAT, 8 (3.12%) with positive both histology and RUT and 7 (2.73%) with positive histology and FAT. The sensitivity, specificity and positive predictive values for RUT were as follows: 97.27%, 85.71% and 99.20% respectively and 96.88%, 85.71% and 99.20% respectively for FAT. Conclusions: RUT or FAT in patients with positive serological test could be used for rapid diagnosis of active H. pylori infection with good sensitivity and specificity without waiting for the results of histology or culture.
Localization of Sugar Residues in the Stomach of Three Species of Monkeys (Tupaiidae glis, Nycticebus cocang and Callithrix jacchus) by Lectin Histochemistry
Fayed,Masoud Hassan; Elnasharty,Mohamed; Shoaib,Mahmoud;
International Journal of Morphology , 2010, DOI: 10.4067/S0717-95022010000100016
Abstract: the stomach of three species of non-human primates was investigated by lectin histochemistry to clarify the staining affinity and distribution patterns of their sugar residues. all gastric regions, with little differences between the deep and superficial parts of the same region, were rich in. in n-acetylglucosamine and/or neuraminic acid. although, the superficial regions of the gastric mucosa were scanty in n-acetylgalactosamine, a- d-glucose and a -d-mannose, the deep parts of the gastric mucosa were rich in these sugars. in conclusion, there is a difference among the mucosubstances of surface and foveolar mucous cells, mucous neck cells, and gastric gland cells. this indicates heterogeneous composition of gastric mucus, or mucus molecules with variations in the degree of glycosylation of their oligosaccharide chains in the different cells which suggest that lectin binding affinity in the gastric mucosa correlated mostly to the degree of cellular differentiation.
Localization of Sugar Residues in the Stomach of Three Species of Monkeys (Tupaiidae glis, Nycticebus cocang and Callithrix jacchus) by Lectin Histochemistry Localización de los Residuos de Azúcar en el Estómago de Tres Especies de Monos (Tupaiidae glis, Nycticebus cocang y Callithrix jacchus) por Histoquímica de Lectina
Masoud Hassan Fayed,Mohamed Elnasharty,Mahmoud Shoaib
International Journal of Morphology , 2010,
Abstract: The stomach of three species of non-human primates was investigated by lectin histochemistry to clarify the staining affinity and distribution patterns of their sugar residues. All gastric regions, with little differences between the deep and superficial parts of the same region, were rich in. in N-acetylglucosamine and/or neuraminic acid. Although, the superficial regions of the gastric mucosa were scanty in N-acetylgalactosamine, a- D-glucose and a -D-mannose, the deep parts of the gastric mucosa were rich in these sugars. In conclusion, there is a difference among the mucosubstances of surface and foveolar mucous cells, mucous neck cells, and gastric gland cells. This indicates heterogeneous composition of gastric mucus, or mucus molecules with variations in the degree of glycosylation of their oligosaccharide chains in the different cells which suggest that lectin binding affinity in the gastric mucosa correlated mostly to the degree of cellular differentiation. El estómago de tres especies de primates no humanos fue investigado por histoquímica de lectinas para determinar la afinidad de tinción y los patrones de distribución de sus residuos de azúcar. Todas las regiones gástricas, con peque as diferencias entre las partes profundas y superficiales de la misma región, eran ricas en N-acetilglucosamina y/o ácido neuramínico. Si bien, las regiones superficiales de la mucosa gástrica eran escasas en N-acetilgalactosamina, a-D-glucosa y a-D-manosa, las partes profundas de la mucosa gástrica eran ricas en estos azúcares. En conclusión, existe una diferencia entre las mucosustancias de la superficie y células mucosas foveolares, células mucosas del cuello y células de las glándulas gástricas. Esto indica una composición heterogénea de la mucosa gástrica, o moléculas de moco con variaciones en el grado de glicosilación de sus cadenas de oligosacáridos en las diferentes células, sugieriendo que la afinidad de union de lectinas en la mucosa gástrica se relacionada principalmente con el grado de diferenciación celular.
Performance Analysis of Observation Based Cooperation Enforcement in Ad Hoc Networks
Abeer Ghandar,Eman Shabaan,Zaky Taha Fayed
International Journal of Computer Science Issues , 2011,
Abstract: Node misbehavior due to selfish or malicious behavior could significantly degrade the performance of MANET because most existing routing protocols in MANET aim to find the most efficient path. Overhearing and reputation based cooperation schemes have been used to detect and isolate the misbehaving nodes as well as to force them to cooperate. Performance analysis has been done for the network traffic using OCEAN over DSR on ns2 while considering the low energy levels for mobile nodes. Throughput, energy level, routing packets and normalized routing overhead are analyzed for OCEAN and normal DSR to show the impact of OCEAN on the overall network performance.
Fluorescence quenching of aromatic hydrocarbons by nitroxide radicals: a mechanismatic study
Tarek A. Fayed,Gunter Grampp,Stephan Landgraf
International Journal of Photoenergy , 1999, DOI: 10.1155/s1110662x99000306
Abstract: The fluorescence quenching of phenanthrene (Phen), 9-cyanophenanthrene (CPhen), 9-cyanoanthracene (CA), perylene (Per), 9,10-dicyanoanthracene (DCA), and 9,10-diphenylanthracene (DPA) using stable nitroxide radicals as quenchers has been studied by steady state and flash photolysis measurements. Both linearity and deviation from linearity in the Stern-Volmer plots have been observed. The active sphere model was used to discuss the upward curvature of the Stern-Volmer plots in case of Per, DCA, and DPA. The bimolecular quenching rate constant (kq) of Phen, CPhen and CA was found to be diffusion controlled while in other cases it is lower than the diffusion limit. On the basis of flash photolysis measurements as well as the overlap between the emission spectra of hydrocarbons and the absorption spectra of radicals, a resonance energy transfer mechanism is taken place in case of Per, DPA, DCA, and CA. For Phen and CPhen where the energy gap between the first excited singlet and the nearest lower triplet state is small, an induced intersystem crossing was suggested. Finally, the quenching process was discussed in terms of the free energy dependence ( ”G) of the electron transfer from nitroxide radicals to the excited hydrocarbons.
Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis  [PDF]
Hasan Sedeek Mahmoud, Ali A. Ghweil, Shamardan E. Bazeed, Hanan M. Fayed, Mona M. Abdel Meguid
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.56010
Abstract: Background: Bleeding esophageal varices (OVs) due to portal hypertension are one of the major complications with high mortality in liver cirrhosis. So, early detection and management are mandatory. Aim: To evaluate the role of Von Willebrand factor (VWF) in predicting the presence of OVs. Patients and Methods: 62 patients with liver cirrhosis representing different Child-Pugh classes were included. The diagnosis of liver cirrhosis was based on the combination of clinical, laboratory and US examinations. All included patients underwent the following investigations: complete blood count, liver function tests (ALT, AST, serum bilirubin, albumin and total protein, prothrombin time (PT) and concentration (PC), INR and serum alkaline phosphatase), serum creatinine, Von Willebrand factor antigen (VWF-Ag) measurement and abdominal US. Upper endoscopic evaluation was done to detect presence or absence of varices (esophageal or gastric) and/or PHG. Results: 38 males and 24 females with their mean age (46 ± 12 years old) were included. Plasma Von Willebrand factor-Ag level was significantly higher in patients with OVs than those without varices (P value = 0.000). Also, its level was significantly higher in patients with higher grade of OVs, G3 than those with G1 or G2 (P value = 0.000). Patients with large OVs including those with G2 and G3 showed significantly higher values of VWF than those with small OVs (NO and G1) (P value = 0.000). VWF was independent predictor for detecting the presence of OVs with good sensitivity (90), specificity (77.3) and accuracy (85.5) at a cutoff value of 1.74 U/ml. Also it was an independent predictor for detecting the presence of large OVs with good sensitivity (91.2), specificity (85.7) and accuracy (88.7) at a cutoff value of 2.16 U/ml. Conclusion: VWF-Ag could be used as a non invasive laboratory independent predictor for the detection of OVs.
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