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OALib Journal期刊

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Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*  [PDF]
Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104366
Abstract:
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two sequences (2 × 2) with a 7-day washout period between each dose in 28 healthy volunteers. Subjects were randomly assigned to each of the administration sequences. The pharmacokinetic parameters evaluated were: Cmax, AUC0-t and AUC0-∞. For the bioequivalence analysis, the AUC0-t was calculated from the time of administration to the 12th hour, posology requested for the medication test, by the trapezoidal method; Software: Excel. The means and Confidence Intervals were compared between 80% - 125% for the quotient of Cmax, Tmax, AUC0-t and AUC0-∞. Results: Cmax 8.3529 ± 1.9176 μg/mL vs. 7.7175 ± 2.1751 μg/mL, Tmax 0.75 h vs. 1.25 h, AUC0-12 25.9560 ± 4.9846 μg/mL/hr vs. 24.9015 ± 5.1507 μg/mL/ hr and AUC0-∞ 27.0147 ± 5.1099 μg/mL/hr vs. 25.6400 ± 5.1144 μg/mL/h, respectively. 95% IC: Cmax 106.26% - 107.85%, AUC0-12 101.11% - 101.78% and AUC0-∞ 100.53% - 102.94%. Conclusion: The test formulation Ketoprofen 150 mg LP, manufactured by LETI S.A.V. Laboratories, is bioequivalent with respect to the reference product ProfenidBI 150 mg controlled release tablets, manufactured by Sanofi-Aventis Pharmaceuticals LTDA Laboratories, as the Values obtained from AUC and Cmax were maintained in the range of 80% - 125%.
There are Two Different Language Systems in the Brain  [PDF]
Alfredo Ardila
Journal of Behavioral and Brain Science (JBBS) , 2011, DOI: 10.4236/jbbs.2011.12005
Abstract: In this paper it is emphasized that human language has two rather different dimensions corresponding to two different language systems: lexical/semantic and grammatical. These two language systems are supported by different brain structures (temporal and frontal), and based in different learning strategies (declarative and procedural). In cases of brain pathology, each one can be independently impaired (Wernicke aphasia and Broca aphasia). While the lexical/semantic language system may have appeared during human evolution long before the contemporary man, the grammatical language system probably represents a relatively recent acquisition. Language grammar may be the departing ability for the development of the metacognitive executive functions and is probably based in the ability to internally represent actions.
The Light as Composed of Longitudinal-Extended Elastic Particles Obeying to the Laws of Newtonian Mechanics  [PDF]
Alfredo Bacchieri
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.59092
Abstract:

It is shown that the speed of longitudinal-extended elastic particles, emitted during an emission time T by a source S at speed u (escape speed toward the infinity due to all the masses in space), is invariant for any Observer, under the Newtonian mechanics laws. It is also shown that a cosmological reason implies the light as composed of such particles moving at speed u (function of the total gravitational potential). Compliance of c with Newtonian mechanics is shown for Doppler effect, Harvard tower experiment, gravitational red shift and time dilation, highlighting, for each of these subjects, the differences versus the relativity.

A Feasible Experiment Contrary to the 2nd Postulate of SR  [PDF]
Alfredo Bacchieri
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.69139
Abstract: Assuming the light as composed of longitudinal-extended elastic (and massive) particles emitted during an emission time T at speed c (=u) (with u the escape speed from all the masses, toward the infinity), it is shown that c is invariant (under the Newtonian mechanics laws), for an Observer fixed to the initial emission point Ep (the point where the emission starts), in spite of any motion of the source (of light) with respect to Ep. On the contrary, an Observer, in motion from Ep during the emission, will state (indirectly) a Galilean variation of c which can be proved and evaluated by an appropriate feasible experiment described here.
Effect of Breed and Sex on Pork Meat Sensory Evaluation  [PDF]
Sandra Rodrigues, Alfredo Teixeira
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.57070
Abstract:

This work had an objective to evaluate the sensory quality of two categories of pork meat from a commercial pork meat and a selected meat from the Portuguese black pork (Preto Alentejano breed). Sixteen animals were used, 8 females and 8 males from each breed. Animals had 80 - 100 kg of live weight. The longissimus muscle between the 5th thoracic vertebra and the 10th lumbar vertebra was used in the analysis. Sensory analysis was performed by a trained taste panel of 10 elements, in 5 sessions. All evaluation conditions were standardized, and the attributes studied were odor intensity, toughness, juiciness and flavor intensity. The taste panel found differences mainly between breeds. The panellists scored Preto Alentejano meat as being juicier, tenderer, and with richer taste than Commercial meat. The higher juiciness score of Preto Alentejano meat was probably attributable to the higher intramuscular fat content compared with Commercial meat. The Commercial pork was characterized mainly by high toughness.

La epidemia de influenza (Gripe Asiática) de 1957 y la patología prenatal
ALFREDO WIEDERHOLD,ALFREDO GANTZ
Revista chilena de pediatría , 1959,
Abstract:
Phenomenal Consciousness and the Sensorimotor Approach. A Critical Account  [PDF]
Alessandro Dell’Anna, Alfredo Paternoster
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.34064
Abstract: The paper discusses some recent suggestions offered by the so-called sensorimotor (or enactivist) theorists as to the problem of the explanatory gap, that is, the alleged impossibility of accounting for phenomenal consciousness in any scientific theory. We argue in the paper that, although some enactivist theorists’ suggestions appear fresh and eye-opening, the claim that the explanatory gap is (dis)solved is much overstated.
Climate Action Plan for the City of La Paz, BCS, Mexico: A Tool for Public Policy in a Coastal City  [PDF]
Antonina Ivanova, Alfredo Bermudez- Contreras
Current Urban Studies (CUS) , 2014, DOI: 10.4236/cus.2014.23024
Abstract: As a result of its coastal location and severe water scarcity condition, the city of La Paz, Baja Cali-fornia Sur, Mexico, is extremely vulnerable to the impacts of climate change. This work presents the main findings of the Climate Change Action Plan for the City of La Paz and Neighbouring Areas (PACCLAP) including its development process and the main results of its two larger components: first, the vulnerability to climate change in the area and the adaptation measures suggested; and second, the local greenhouse gas emissions inventory and the recommended mitigation measures. In addition, the proposed actions have important impacts directly related with the Municipality Development Plan, thus making the PACCLAP a valuable instrument to support current and future decision makers in the formulation of public policies to foster a more sustainable development and improve the wellbeing of the local society.
Ruralia, tradicionalismo y población en la puna de Jujuy durante el siglo XX
Bolsi,Alfredo;
Mundo agrario , 2005,
Abstract: the growth of the population pune?a during century xx is from the evolution of three central circumstances. first, it consists of which the society pune?a, specially the rural one, has been, and largely it is it, ";a traditional"; society, that is to say, nonmodern, preindustrial, with social structure little differentiated, cultural guidelines differentials. the other is related to the process of joint between that traditional society and modern, the capitalist one, extra-pune?a. the conjecture is that the consolidation of capitalism in the argentine northwest from the last third of century xix did not move nor replaced the traditional society: it coexisted with her during decades generating substantial changes in numerous aspects. third it has to do with the action of the state: during the first decades of the xx it operated at least in the context of the positivismo, associated with the concept of development - nondistant to the one of progress. through the progress, the traditional society transforms itself into a rational, secular society, with differentiated social structures.
Entre la pluralidad y la universalidad, desafíos para los derechos humanos
Culleton,Alfredo;
Discusiones Filosóficas , 2011,
Abstract: this article shows the problems in the defense of human rights in a globalized world. it makes clear that human rights, despite the theoretical controversy, may be conceived as a moral category, made up of values that are interrelated with human dignity. it also shows that though they are classified as supralegal, because they exist independently of the legal recognition of states, their warranty and operation depend on the incorporation of these values to the national and international legal systems, so that they commit the centers of power to their observance and protection.
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