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Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*  [PDF]
Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104366
Abstract:
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two sequences (2 × 2) with a 7-day washout period between each dose in 28 healthy volunteers. Subjects were randomly assigned to each of the administration sequences. The pharmacokinetic parameters evaluated were: Cmax, AUC0-t and AUC0-∞. For the bioequivalence analysis, the AUC0-t was calculated from the time of administration to the 12th hour, posology requested for the medication test, by the trapezoidal method; Software: Excel. The means and Confidence Intervals were compared between 80% - 125% for the quotient of Cmax, Tmax, AUC0-t and AUC0-∞. Results: Cmax 8.3529 ± 1.9176 μg/mL vs. 7.7175 ± 2.1751 μg/mL, Tmax 0.75 h vs. 1.25 h, AUC0-12 25.9560 ± 4.9846 μg/mL/hr vs. 24.9015 ± 5.1507 μg/mL/ hr and AUC0-∞ 27.0147 ± 5.1099 μg/mL/hr vs. 25.6400 ± 5.1144 μg/mL/h, respectively. 95% IC: Cmax 106.26% - 107.85%, AUC0-12 101.11% - 101.78% and AUC0-∞ 100.53% - 102.94%. Conclusion: The test formulation Ketoprofen 150 mg LP, manufactured by LETI S.A.V. Laboratories, is bioequivalent with respect to the reference product ProfenidBI 150 mg controlled release tablets, manufactured by Sanofi-Aventis Pharmaceuticals LTDA Laboratories, as the Values obtained from AUC and Cmax were maintained in the range of 80% - 125%.
Anatomía y desarrollo del fruto en Piriqueta y Turnera (Turneraceae)
Gonzalez,Ana Maria;
Bolet?-n de la Sociedad Argentina de Bot??nica , 2010,
Abstract: the aims of this work were to describe the morphology, anatomy and development of the fruits of 12 species of piriqueta and 30 species of turnera; to identify the structures related to the process of dehiscence of the capsule; and to verify the occurrence of standards carpological structure between the studied species. the ovary is 3-carpellar, syncarpous, unilocular with parietal placentation and has the same anatomical structure in all studied species. the outer and inner epidermises are single-layered with stomata; the ovarian mesophyll is composed by parenchyma, with three dorsal and three marginal vascular bundles. during the fruit development, the external epidermis develops a papillose epicarp in piriqueta species. the mesocarp develops from the cells of the middle zone of the carpel. the mechanic stratum is formed by brachysclereids, developing from cells of the outer, median or inner layers of the ovarian mesophyll. two main distributional patterns can be recognised: a mechanic stratum formed by continuous cylinder or clusters of brachysclereids. the first type determines smooth fruits, and the last form granular, verrucose, or tuberculate fruits. the capsules are loculicidal, with dehiscence lines characterized by the presence of macrosclereids, longitudinally dispose at the inner side of the carpellar dorsal bundle. we conclude that different types of pericarp are a post-fertilization feature, because the structure of the ovary is exactly the same in all species. we analyze the anatomy of the fruit in relation to the current taxonomic arrangement.
Enfermeira obstetra: heran?a de parteira e heran?a de enfermeira
Riesco, Maria Luiza Gonzalez;
Revista Latino-Americana de Enfermagem , 1998, DOI: 10.1590/S0104-11691998000200003
Abstract: there are differences in the generation of nursing and midwifery professions that are in the history of professional practice and teaching. the social representation theory is useful as a framework to study the way obstetrics was inserted in nursing, to understand why teaching was united and to make explicit the reflexion on these transformations to the professional practice. a preliminar analysis points out that the consolidation of the social representation of the obstetric nurse has been done with difficulties, as in nursing context, the reified and the consensual universes of thinking related to this question rarely are convergent.
Hallazgo de una nueva especie de Agarista (Ericaceae) en Jalisco, México.
Luz Maria Gonzalez V.
Acta botánica mexicana , 1989,
Abstract:
Los profesores y la transmisión de la historia argentina reciente: entre el currículum y el contexto
Maria Paula Gonzalez
Práxis Educativa , 2008,
Abstract: The aim of this article is to analyze the incorporation of the recent past in Argentina – as much as teaching content as celebration – through the study of problems and questions that appear in schools and among teachers. Through interviews of middle school teachers from the city and state of Buenos Aires – the principal educational actors – we can identify that tensions relate to the history of the study of history, which limited, encouraged or resisted the nearby history of the complex and traumatic 1970s. In this way, we can observe that, with certain difficulties and resistances, the school is perceived as a space for the transmission and construction of memory.
Leprosy anetoderma lesions
Gonzalez Sonia Maria Voss
Revista do Instituto de Medicina Tropical de S?o Paulo , 2004,
Abstract:
"La Evaluación del Riesgo en la Agencia de Seguridad Alimentaria y Nutrición"
Ana Maria TRONCOSO GONZALEZ
Revista de Toxicología , 2009,
Abstract:
Anatomía y desarrollo del fruto en Piriqueta y Turnera (Turneraceae) Anatomy and development of fruits in Piriqueta and Turnera (Turneraceae)
Ana Maria Gonzalez
Boletín de la Sociedad Argentina de Botánica , 2010,
Abstract: En este estudio se analiza la anatomía, estructura y desarrollo de los frutos en 12 especies de Piriqueta y 30 especies de Turnera; con el objetivo de identificar la estructura involucrada en la dehiscencia y verificar la existencia de patrones en la organización del fruto entre las especies analizadas. El ovario es sincárpico, tricarpelar, unilocular con placentación parietal, presentando la misma estructura en todas las especies. Ambas epidermis carpelares son uniestratificadas y tienen estomas, el mesófilo es parenquimático con 3 haces dorsales y 3 marginales. Durante el desarrollo del fruto, la epidermis externa forma un epicarpo papiloso en las especies de Piriqueta. El mesocarpio deriva de los estratos medios del ovario, formando un estrato mecánico de braquiesclereidas. Estas esclereidas pueden organizarse como un cilindro continuo determinando frutos de superficie lisa o agruparse en nidos, unidos o no, determinando así frutos granulares, verrugosos, o tuberculados. Las cápsulas son loculicidas, con línea de dehiscencia formada por macroesclereidas dispuestas longitudinalmente en el fruto, paralelas al haz carpelar dorsal. Se concluye que los diferentes tipos de pericarpio son un rasgo post-fecundación, dado que la estructura del ovario es exactamente la misma en todas las especies analizadas. Se analiza la anatomía del fruto en relación al esquema taxonómico actualizado. The aims of this work were to describe the morphology, anatomy and development of the fruits of 12 species of Piriqueta and 30 species of Turnera; to identify the structures related to the process of dehiscence of the capsule; and to verify the occurrence of standards carpological structure between the studied species. The ovary is 3-carpellar, syncarpous, unilocular with parietal placentation and has the same anatomical structure in all studied species. The outer and inner epidermises are single-layered with stomata; the ovarian mesophyll is composed by parenchyma, with three dorsal and three marginal vascular bundles. During the fruit development, the external epidermis develops a papillose epicarp in Piriqueta species. The mesocarp develops from the cells of the middle zone of the carpel. The mechanic stratum is formed by brachysclereids, developing from cells of the outer, median or inner layers of the ovarian mesophyll. Two main distributional patterns can be recognised: a mechanic stratum formed by continuous cylinder or clusters of brachysclereids. The first type determines smooth fruits, and the last form granular, verrucose, or tuberculate fruits. The capsules are locu
Gamma convergence of an energy functional related to the fractional Laplacian
Maria D. M. Gonzalez
Mathematics , 2008,
Abstract: We prove a Gamma-convergence result for an energy functional related to some fractional powers of the Laplacian operator, with two singular perturbations (one in the interior and one on the boundary).
Social Responsibility Networks (SRN): The Role of the International Civil Society in Redressing the Negative Effects of Globalization at the Local Level Social Responsibility Networks (SRN): The Role of the International Civil Society in Redressing the Negative Effects of Globalization at the Local Level
Maria Alejandra Gonzalez-Perez
AD-minister , 2008,
Abstract: Evidencias, tanto teóricas como empíricas, indican que la globalización de laeconomía ha intensificado la exclusión social, los problemas medio ambientales y haexacerbado desigualdades en materia social y laboral. Para revertir estas situacionesse requiere de sistemas transnacionales de gobernabilidad legítimos y transparentes,que cuenten con la participación activa y reconocida de los trabajadores.Este documento se basa en una investigación empírica en la cual se presentaun modelo de participación transnacional de los actores de la sociedad civil(incluyendo los sindicatos y otras organizaciones de trabajadores), así como tambiénlas corporaciones privadas y las agencias gubernamentales. De esta manera se desarrolla una plataforma que opera como un sistema de responsabilidad socialcuyo alcance sobrepasa a la responsabilidad social empresarial (RSE). There is both theoretical and empirical evidence which indicates that the processes of globalization have intensified the onset of social exclusion and environmental problems. Globalized processes may also exacerbate inequalities that, in order to be readdressed, require transnational, transparent, accountable and participative governance systems, with an active and recognised contribution by the local community in the amelioration of these problems. This paper focuses on transnational participation of civil society actors as well as private corporations and state agencies, which together provide a platform for the development of a broader scope for corporate social responsibility (CSR).
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