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OALib Journal期刊

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Variability of Acid-Base Status in Acetate-Free Biofiltration 84% versus Bicarbonate Dialysis
Harzallah Kais,Hichri Nourredine,Mazigh Chakib,Tagorti Mohamed
Saudi Journal of Kidney Diseases and Transplantation , 2008,
Abstract: The ultimate goal of hemodialysis (HD) treatment is to achieve the highest level of efficacy in the presence of maximal clinical tolerance. With an aim to offer good hemodynamic stability, as observed during the acetate-free biofiltration 14% (AFB 14%) to patients who are intolerant to bicarbonate dialysis (BD) and with less cost, we have developed since June 1994, a new HD technique, namely AFB 84%. This study was carried out to analyze acid-base variations during the AFB 84% in comparison to BD in hemodynamically stable patients on regular HD. This was a prospective randomized crossover study carried out on 12 patients (6 males and 6 females) for a total of 144 HD sessions (72 BD and 72 AFB 84%). Patients with decompensated cardiomyopathy, respiratory diseases or uncontrolled hypertension were not included in the trial. All the patients were treated with BD or AFB 84%; the latter is characterized by the absence of acetate in the dialysate and a complete correction of buffer balance by post-dilutional infusion of bicarbonate-based replacement solution. The comparison of pre-dialysis arterial acid-base and blood-gas parameters revealed no significant differences of pH, HCO 3 - and paCO 2 levels between the two techniques. Analysis of post-dialysis parameters showed that, among patients dialyzed with BD, there was over correction of metabolic acidosis with a tendency towards metabolic alkalosis. In contrast, in patients dialyzed with AFB 84%, we observed a significant improvement in pH and HCO 3 - levels but the increase in paCO2 level was not significant. A comparison of these parameters between the two techniques showed statistically significant difference in pH, HCO3 - and paCO2 levels, but not for paO2 level. AFB 84% can offer some important advantages with the complete absence of acetate from the substitution fluids, and permits a better correction of metabolic acidosis than BD, without causing alkalosis.
Endothelial Nitric Oxyde Synthase Gene Polymorphisms in a Tunisian Deep Vein Thrombosis Group  [PDF]
Nedra Grira, Nadia Ben Abdelhafidh, Manel Ayoub, Rihab Sendesni, Bochra Adib, Najla Stambouli, Salah Othmani, Zied Aouni, Chakib Mazigh
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.49004
Abstract: Deep vein thrombosis (DVT) is a multi-factorial disease involving both genetic and acquired risk factors. The objective of this study was to determine the frequencies of endothelial nitric oxide synthase (eNOS) gene polymorphisms G894T (rs1799983) and T-786C (rs2070744) to assess the role of these polymorphisms as a potential risk factor in the development of DVT. Methods: In this case-control study, we included 32 patients with deep vein thrombosis (DVT) and 31 healthy control subjects. Clinical characteristics were collected. Lipids plasma concentrations were determined by the colorimetric method. Genotyping for the polymorphisms was performed by restriction fragment length polymorphism (PCR-RFLP) method. Results: We had found that the eNos G894T genotype G/T was significantly increasing the risk of DTV (P = 0.042, OR = 3.9; 95% CI = 1.09 to 13.92). But no association of the eNOS T-786C variant and DVT was found. For the eNOs T-786C polymorphism, the frequency of the T/T genotype was 87.5% in patients (with an allelic frequency of T Allele equal to 91%). No significant difference was noted between the two groups (P > 0.05). Conclusion: The eNOs G894T polymorphism seems to be in association with DVT and may be considered as a risk factor, but this is not the case for the T-786C polymorphism.
Endothelial Nitric Oxide Synthase (eNOS) Glu298Asp Gene Polymorphism (G894T) as a Risk Factor for Type 2 Diabetes Mellitus in the Tunisian Population  [PDF]
Rihab Sendesni, Nedra Grira, Oussama Lamine, Sana Aboulkassem, Manel Ayoub, Nejla Stambouli, Ouertani Haroun, Chakib Mazigh, Zied Aouni
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104171
Abstract:
Introduction: Diabetes mellitus is a chronic disease whose global expansion gives it the characteristics of a pandemic. Diabetes risk factors are well known. In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. Methods: We conducted a prospective case-control study in which we included 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. Results: The analysis of our results shows a statistically significant elevated TG values (p < 10﹣3), Lp (a) (p < 10﹣3), and CRP-us (p < 10﹣3) in type 2 diabetes compared with controls. The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. In our series, we did not notice any significant difference in genotype or allele frequency between diabetics with and without degenerative complications. Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. His role in the development of degenerative complications remains proved.
Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group  [PDF]
Rihab Sendesni, Dhaker Lahidheb, Manel Ayoub, Nedra Grira, Dhekra Lafi, Nejla Stambouli, Mabrouka El Oudi, Ezzedine Ghazouani, Habib Haouala, Zied Aouni, Chakib Mazigh
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102635
Abstract:
Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 103) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 103. The hsCRP values are inversely correlated with the HDLc values. No association was found between IL 8 and the various lipid parameters. Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc. Conclusion: Significant correlation was found between inflammatory markers and lipids profile. This may explain the role of inflammation in the development of cardiovascular disease.
Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients  [PDF]
Grira Nadra, Sandesni Rihab, Lamine Ossama, Aboulkassem Sana, Ayoub Manel, El Oudi Mabrouka, Stambouli Najla, Lahidheb Thaker, Haouala Habib, Mazigh Chakib, Aouni Zied
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104214
Abstract:
Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.
Histoire d’un voile
Monia Mazigh
Voix Plurielles , 2012,
Abstract: Mazigh, Monia. Création
Acoustic measures of the cry characteristics of healthy newborns and newborns with pathologies  [PDF]
Yasmina Kheddache, Chakib Tadj
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68097
Abstract: Several hypotheses have been formulated as a result of observing spectrograms of the audio signals of the newborn infant cry in numerous studies. Our study is based on a few of these hypotheses. The purpose of this article is to differentiate pathological crying from healthy crying through acoustic cry analysis based on neurophysiological parameters of newborns. The automatic estimation of the characteristics of relevant cry signals, such as phonation, hyperphonation, and dysphonation, expressed as percentages, as well as unvoiced sound and mode change percentages, have enabled us to distinguish among the pathologies selected for this study. The results obtained have helped us to make quantitative associations between cry characteristics and pathological conditions affecting newborns.

Characterization of Pathologic Cries of Newborns Based on Fundamental Frequency Estimation  [PDF]
Yasmina Kheddache, Chakib Tadj
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B057
Abstract:

The majority of the sick babies seem in good health at birth and early diagnosis of the various pathologies that can afflict newborn is crucial. For this reason we introduce in this paper the use of the fundamental frequency and the different modes of cries as Hyper-phonation, phonation and high pitched cries to differentiate the pathological cries from the cries of the healthy babies. The automatic estimation of these characteristics enabled us to establish a quantitative characterization of healthy newborn cries and pathologic newborn cries. The results obtained agree with the spectrographic analysis carried out on the healthy and pathologic cries of the newborns.

Splitting of Gaussian Models via Adapted BML Method Pertaining to Cry-Based Diagnostic System  [PDF]
Hesam Farsaie Alaie, Chakib Tadj
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B058
Abstract:

In this paper,we make use of the boosting method to introduce a new learning algorithm for Gaussian Mixture Models (GMMs) called adapted Boosted Mixture Learning (BML). The method possesses the ability to rectify the existing problems in other conventional techniques for estimating the GMM parameters, due in part to a new mixing-up strategy to increase the number of Gaussian components. The discriminative splitting idea is employed for Gaussian mixture densities followed by learning via the introduced method. Then, the GMM classifier was applied to distinguish between healthy infants and those that present a selected set of medical conditions. Each group includes both full-term and premature infants. Cry-pattern for each pathological condition is created by using the adapted BML method and 13-dimensional Mel-Frequency Cepstral Coefficients (MFCCs) feature vector. The test results demonstrate that the introduced method for training GMMs has a better performance than the traditional method based upon random splitting and EM-based re-estimation as a reference system in multi-pathological classification task.


SPECTRAL ANALYSIS OF BUCK AND SEPIC CONVERTERS
CHAKIB ALAOUI
International Journal of Engineering Science and Technology , 2011,
Abstract: Switched mode power converters generate harmonic currents, which will be injected into the utility grid, causing distortion of the utility waveform. They also become a source for the generation of EMI, which may affect the communication systems. This work is about the design and evaluation of the two most frequently used SMPS used in step down mode of operation: the Buck converter and the Sepic converter working in step-down mode of operation. These converters were designed using optimized equations for their components ratings. Simulation results show that although the Buck output voltage is low in harmonics, it has high harmonic contents in currents circulating in its inductor and diode, and hence requires strong filtering. The Sepic converterhas lower harmonic contents than the Buck converter.
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