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Effects of Vitamin D Supplementation on Lipid Profile and Plasma Glucose of Preeclamptic Women in Ibadan, Nigeria  [PDF]
Ayobola Abimbola Sonuga, Modupe Fisayo Asaolu, Oyebola Oluwagbemiga Sonuga
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104410
Abstract:
Biochemical metabolites are implicated in preeclampsia, which include elevated plasma concentration of Triglycerides (TG), Low Density Lipoprotein Cholesterol (LDLC), total lipids and reduced High Density Lipoprotein Cholesterol (HDLC) concentrations and significant reductions in fasting plasma glucose, and serum insulin homeostasis model of assessment. Vitamin D supplementation seems to be a possible target for intervention and possible improved pregnancy outcomes in preeclampsia. Therefore, this study aimed at determining the effects of Vitamin D supplementation on the Lipid Profile, and random plasma glucose levels of preeclamptic women in Ibadan, Nigeria. This interventional study was carried out at the Antenatal clinic of Obstetrics and Gynecology Departments of University College Hospital Ibadan and Adeoyo Maternity Clinic, Yemetu, Ibadan, Nigeria. 120 pregnant women aged 18 to 35 were recruited; 40 normotensive pregnant women served as control; 40 randomly chosen preeclamptic women were placed on oral vitamin D supplement of 1000 IU/day for 8 weeks and 40 preeclamptic women were given no supplement. Blood samples were taken at study baseline (22 weeks), after 8 weeks of supplementation (3rd trimester) and 3 to 5 days postpartum in all groups to quantify serum vitamin D, random glucose and Lipid profile. Vitamin D was quantified by Enzyme Linked Immunosorbent Assay (ELISA), glucose status by glucose oxidase method and lipid profile by standard methods. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) soft version 17.0 and subjected to One way analysis of Variance (ANOVA) and Student’s t test. Results showed a significant increase (p < 0.05) in levels of TG, LDLC, random plasma glucose and a decrease (p < 0.05) in HDLC levels in the preeclamptic groups when compared with normotensive women in second and third trimester. After vitamin D supplementation, there was a significant reduction (p < 0.05) in Total Cholesterol (TC), TG, LDLC levels and an increase in HDLC (p < 0.05) (4.49 ± 0.38, 1.51 ± 0.22, 3.45 ± 0.57, 1.87 ± 0.29) vs. (5.96 ± 0.49, 2.30 ± 0.20, 5.90 ± 0.36, 1.07 ± 0.28) respectively. Random plasma glucose level was reduced (5.7 ± 0.5 vs. 6.01 ± 0.43), though not statistically significant (p > 0.05). Vitamin D supplementation is important in ameliorating dyslipidemia associated with preeclampsia.
Physico-Chemical Characterization of Akoko Mined Kaolin Clay  [PDF]
Abimbola George Olaremu
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2015, DOI: 10.4236/jmmce.2015.35038
Abstract: Over the past several decades, kaolin has been intensively used in ceramics formulation by the indigene of Erusu Akoko, in south western Nigeria. Kaolin is a clay mineral with wide technological applications in the industry. It finds applications in fiberglass, paper, rubber, tires, ceramics, cements, latex, paint, printing inks, catalysts for petroleum refining, medicines, water treatment, cosmetics and others. In the present work, we studied the mineralogy of Erusu clay that had been in use for several generations without understanding the physico-chemical properties. Samples of the material were pre-treated and subjected to analysis. From our results, Akoko clay exhibited decompositional water loss of 13.23% and 13.14% in air and argon respectively at 1000°C. The Brunanuer-Emmett-Teller (BET) analysis showed that the kaolin clay was majorly a mesoporous material and the isotherm was of the type iv. The micropore surface area obtained from t-plot is 9.06 m2/g indicating that the materials also contain micropore with size and volume of 15.611 ? and 0.265 cc/g respectively. The XRD, IR and TEM analysis confirmed the presence of Kaolin and Quarts as the major constituents of Akoko clay.
Changes in serum markers of oxidative status in Wistar rats following exposure to kerosene
Ayobola Abolape Iyanda
Journal of Experimental and Integrative Medicine , 2013, DOI: 10.5455/jeim.271012.or.051
Abstract: Objective: Kerosene is commonly available in many parts of the developing world where it is used as fuel for lighting and cooking purposes. Toxic effects of large quantities of kerosene have been reported but there is dearth of data on impact of trace amount of kerosene on mammals. Exposure through either the dermal or oral route is common among humans (kerosene retailers). The aim of the study is to determine the degree of oxidative damage that can result from dermal or oral exposure to trace amount of kerosene. This will be accomplished by utilizing oxidative-stress markers like antioxidant enzymes and product of lipid peroxidation as indices of the study. Methods: Using spectrometric techniques; levels of reduced glutathione (GSH), oxidized glutathione (GSSG) and malondialdehyde (MDA) as well as activities of glutathione reductase, glutathione-S-transferase, catalase, superoxide dismutase and glutathione peroxidase were measured. Results: Administration of rats with 0.4 ml/kg b.wt of kerosene for a period of thirty days resulted in significant decreases in either the level or activities of antioxidants (Zn, Cu, Mn, GSH, antioxidant enzymes) and significant increases in the levels of products of oxidation (MDA, GSSG). Conclusion: The result of this study suggests that constant exposure to trace quantity of kerosene may be capable of inducing oxidative stress in mammals. Therefore steps should be taken to discourage constant exposure to kerosene. [J Exp Integr Med 2013; 3(1): 31-36]
New Matrix Tablet from Okra Gum: Effects of Method of Preparation and Gum Concentration on Tablet Properties  [PDF]
Bakre Lateef Gbenga, Abimbola Zulikha
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.46070
Abstract: The objective of this investigation is to study the effect of methods of preparation and concentration of gum on the compressional and mechanical properties of Okra gum matrix. The compressional behavior of Okra gum matrices prepared by direct compression and wet granulations is analyzed using density measurements, Heckel and Kawakita analysis while the mechanical properties of the formulations were assessed using crushing strength (CS) and friability (FR) as well as CSFR ratio. Formulations prepared by direct compression had lower Pk values than those prepared by wet granulation while there was no significant difference between Py values of formulations prepared by direct compression and wet granulations. Therefore, formulations prepared by direct compression underwent plastic deformation more easily and rapidly than those prepared by wet granulation. The results show that DB values increased with decrease in concentration of the gum and granules undergo higher degree of fragmentation than powders. Formulations containing 90% w/w Okra gum exhibited the highest amount of total plastic deformation and gave the best packing. Tablets prepared by direct compression showed lower bond strength and higher friability values than those prepared by wet granulations. The crushing strength generally decreases with a decrease in the concentration of the gum while there was an inverse relationship between friability and gum concentration. CSFR decreases with a decrease in gum concentration and tablets prepared by wet granulations showed significantly higher values of CSFR (p < 0.001) than those prepared by direct compression. The results suggest that the concentration of gum and the method of preparation of materials for compression are critical factors in the formulation of Okra gum matrices with acceptable compressional and mechanical properties.
SERUM VITAMIN LEVELS IN FEMALE WISTAR RATS ADMINISTERED WITH DIFFERENT DOSES OF PARACETAMOL AND PARACETAMOL/METHIONINE – AN ACUTE STUDY
Iyanda Ayobola Abolape,Adeniyi Francis
International Research Journal of Pharmacy , 2011,
Abstract: Testosterone has been identified to play a role in the metabolism of paracetamol in the CD 1 mouse, resulting in differences in renal presentations of male and female mice. Moreover, alterations have been observed in the serum levels of vitamins in male Wistar rats administered with paracetamol/methionine. The aim of this study is to determine if the sex of an animal plays a role in serum vitamin presentation in the Wistar strain after paracetamol/methionine administration. This will be achieved by comparing observation made from this study with an earlier one on male Wistar rats. Moreover, comparison of presentations at the 4th & 16th hours will be carried out, so as to establish how earlier in the course of exposure to paracetamol/methionine vitamin alteration takes place. Female Wistar Rats consisting of eight rats per group were administered with different doses of paracetamol & paracetamol/methionine (5:1) ranging from 350-5000 mg/kg. Results indicate that significant alterations (p<0.05) in the levels of all the vitamins commenced as early as the 4th hour in both paracetamol & paracetamol/methionine administered groups. Moreover, significant alterations in the female rats parallel those of male rats obtained from an earlier study. Evidence from this study when compared with an earlier one indicates that sex probable plays no role on the impact of paracetamol on serum vitamins in Wistar rats.
Health systems in an interconnected world: a view from Nigeria
Abimbola,Seye;
MEDICC Review , 2011, DOI: 10.1590/S1555-79602011000300010
Abstract: the benefits of an interconnected world for health care remain untapped. as a result of the politics of inequality between rich and poor countries, one or a few health systems are set up as models. every country, irrespective of political or economic status, should be open to learning from others to build relevant and cost-effective systems. to combat the current global challenge of chronic non-communicable diseases, poor countries have the advantage of flexible health systems that are veritable laboratories of health systems research. not only can research conducted in these health systems help harness the potential of mobile communication technologies and informal health providers, it can also help rich country health systems adapt to meet the chronic disease challenge.
Health systems in an interconnected world: a view from Nigeria
Seye Abimbola
MEDICC Review , 2011,
Abstract: The benefits of an interconnected world for health care remain untapped. As a result of the politics of inequality between rich and poor countries, one or a few health systems are set up as models. Every country, irrespective of political or economic status, should be open to learning from others to build relevant and cost-effective systems. To combat the current global challenge of chronic non-communicable diseases, poor countries have the advantage of flexible health systems that are veritable laboratories of health systems research. Not only can research conducted in these health systems help harness the potential of mobile communication technologies and informal health providers, it can also help rich country health systems adapt to meet the chronic disease challenge.
The Boko Haram Uprising and Islamic Revivalism in Nigeria Die Boko-Haram-Unruhen und die Wiederbelebung des Islam in Nigeria
Abimbola Adesoji
Africa Spectrum , 2010,
Abstract: From the 1980 Maitatsine uprising to the 2009 Boko Haram uprising, Nigeria was bedevilled by ethno-religious conflicts with devastating human and material losses. But the Boko Haram uprising of July 2009 was significant in that it not only set a precedent, but also reinforced the attempts by Islamic conservative elements at imposing a variant of Islamic religious ideology on a secular state. Whereas the religious sensitivity of Nigerians provided fertile ground for the breeding of the Boko Haram sect, the sect’s blossoming was also aided by the prevailing economic dislocation in Nigerian society, the advent of party politics (and the associated desperation of politicians for political power), and the ambivalence of some vocal Islamic leaders, who, though they did not actively embark on insurrection, either did nothing to stop it from fomenting, or only feebly condemned it. These internal factors coupled with growing Islamic fundamentalism around the world make a highly volatile Nigerian society prone to violence, as evidenced by the Boko Haram uprising. Given the approach of the Nigerian state to religious conflict, this violence may remain a recurring problem. This paper documents and analyses the Boko Haram uprising, as well as its links with the promotion of Islamic revivalism and the challenges it poses to the secularity of the Nigerian state. Vom Maitatsine-Aufstand 1980 bis zu den Boko-Haram-Unruhen 2009 hat die nigerianische Bev lkerung unter den verheerenden menschlichen und materiellen Kosten ethnisch-religi ser Konflikte gelitten. Die Boko-Haram-Unruhen (Juli 2009) markierten allerdings eine qualitative Ver nderung, denn sie stellten einen Pr zedenzfall dar und verst rkten Versuche konservativer Anh nger des Islam, im s kularen nigerianischen Staat Elemente islamischer Ideologie einzuführen. Angesichts der Empf nglichkeit der Nigerianer für religi ses Denken konnte sich die Boko-Haram-Sekte schnell ausbreiten, erleichtert durch die nach wie vor bestehende konomische Polarisierung der nigerianischen Gesellschaft, die erneut heftig aufgebrochene Konkurrenz der Parteien um die politische Macht und die Ambivalenz einiger lautstarker islamischer Führer, die zwar nicht explizit zum Aufstand aufriefen, aber auch nichts zur Beendigung der Hetze beitrugen und diese nur vorsichtig verurteilten. Diese internen Faktoren und der gleichzeitige weltweite Aufschwung des islamischen Fundamentalismus führten in der hoch volatilen nigerianischen Gesellschaft zu den gewaltsam ausgetragenen Boko-Haram-Unruhen. Die im nigerianischen Staat strukturell angelegte Gef
Gradient estimates for a nonlinear parabolic equation with potential under geometric flow
Abimbola Abolarinwa
Mathematics , 2014,
Abstract: Let $(M, g)$ be an dimensional complete Riemannian manifold. In this paper we prove local Li-Yau type gradient estimates for all positive solutions to the following nonlinear parabolic equation \begin{equation*} (\partial_t - \Delta_g + \mathcal{R}) u(x, t) = - a u(x, t) \log u(x, t) \end{equation*} along the generalised geometric flow. Here $ \mathcal{R} = \mathcal{R} (x, t)$ is a smooth potential function and $a$ is a constant. As an application we derived a global estimate and a space-time Harnack inequality.
Differential Harnack estimates for conjugate heat equation under the Ricci flow
Abimbola Abolarinwa
Mathematics , 2014,
Abstract: We prove certain localized and global differential Harnack inequality for all positive solutions to the geometric conjugate heat equation coupled to the forward in time Ricci flow. In this case, the diffusion operator is perturbed with the curvature operator, precisely, the Laplace-Beltrami operator is replaced with "$ \Delta - R(x,t)$", where $R$ is the scalar curvature of the Ricci flow, which is well generalised to the case of nonlinear heat equation with potential. Our estimates improve on some well known results by weakening the curvature constraints. As a by product, we obtain some Li-Yau type differential Harnack estimate. The localized version of our estimate is very useful in extending the results obtained to noncampact case.
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