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Patrimonio industrial colombiano: la definición de paisajes productivos en la Sabana de Bogotá
Beltrán-Beltrán,Lina Constanza;
Apuntes: Revista de Estudios sobre Patrimonio Cultural - Journal of Cultural Heritage Studies , 2008,
Abstract: the understanding and acknowledgement of colombia's industrial legacy has been dominated by traditional perspectives that when drawing up inventories, enhance the individual object and rule out the dynamics of production that were developed and consolidated. as an alternative, this paper proposes an approach that combines the ideas about industrial heritage and cultural landscapes as a starting point to identify, value and bring together the tangible and intangible heritage of bogota's high plain productive history which gives its industrial cultural identity. as a methodology, three productive processes of which documentation from the pre-columbian era was available are studied and related mutually in three different periods, as part of a production process or as a result of exchange between different regions. the presence of water as a resource for production and distribution is included as a factor in the reconstruction of these landscapes. classifying these traces, three production landscapes were reconstructed, and methodologies are proposed for identifying and valuing the remains of production that could be part of the industrial heritage of colombia.
Héctor Mujica: apuntes para el debate del socialismo en Venezuela
Morán-Beltrán,Lino; Méndez-Reyes,Johan;
Utopìa y Praxis Latinoamericana , 2010,
Abstract: héctor mujica represents one of the most important intellectuals in twentieth-century venezuelan marxism. the ideas guiding this study include his posture regarding history, religion and mass media as well as his thesis about progress, his anti-imperialist posture and especially, socialist theory as an instrument for interpreting and transforming reality.
Las ideas positivistas y evolucionistas en la obra de Laureano Vallenilla Lanz
Méndez-Reyes,Johan; Morán-Beltrán,Lino;
Revista de Filosofía , 2009,
Abstract: laureano vallenilla lanz is one of the most influential intellectuals from venezuela at the end of 19th and beginning of the 20th centuries. he belongs to the generation of theorists who were nourished fundamentally by positivist doctrine and made of it a tool for developing the interpretation of our reality in order to build a stable and prosperous nation. the ideas guiding the present examination gather their posture before history, the individual and society, religion, education, centralism, war and peace.
Héctor Mujica: apuntes para el debate del socialismo en Venezuela
Lino Morán-Beltrán,Johan Méndez-Reyes
Utopia y Praxis Latinoamericana , 2010,
Abstract: Héctor Mujica, representa unos de los intelectuales más importantes del marxismo venezolano del siglo XX. Las ideas que guían el presente estudio, recogen su postura ante la historia, la religión, los medios de comunicación, así como su tesis sobre el progreso y su postura antiimperialista y, de manera muy particular, la teoría socialista como instrumento de interpretación y trasformación de la realidad.
Teaching of evidence-based medicine to medical students in Mexico: a randomized controlled trial
Sánchez-Mendiola Melchor,Kieffer-Escobar Luis F,Marín-Beltrán Salvador,Downing Steven M
BMC Medical Education , 2012, DOI: 10.1186/1472-6920-12-107
Abstract: Background Evidence-Based Medicine (EBM) is an important competency for the healthcare professional. Experimental evidence of EBM educational interventions from rigorous research studies is limited. The main objective of this study was to assess EBM learning (knowledge, attitudes and self-reported skills) in undergraduate medical students with a randomized controlled trial. Methods The educational intervention was a one-semester EBM course in the 5th year of a public medical school in Mexico. The study design was an experimental parallel group randomized controlled trial for the main outcome measures in the 5th year class (M5 EBM vs. M5 non-EBM groups), and quasi-experimental with static-groups comparisons for the 4th year (M4, not yet exposed) and 6th year (M6, exposed 6 months to a year earlier) groups. EBM attitudes, knowledge and self-reported skills were measured using Taylor’s questionnaire and a summative exam which comprised of a 100-item multiple-choice question (MCQ) test. Results 289 Medical students were assessed: M5 EBM=48, M5 non-EBM=47, M4=87, and M6=107. There was a higher reported use of the Cochrane Library and secondary journals in the intervention group (M5 vs. M5 non-EBM). Critical appraisal skills and attitude scores were higher in the intervention group (M5) and in the group of students exposed to EBM instruction during the previous year (M6). The knowledge level was higher after the intervention in the M5 EBM group compared to the M5 non-EBM group (p<0.001, Cohen's d=0.88 with Taylor's instrument and 3.54 with the 100-item MCQ test). M6 Students that received the intervention in the previous year had a knowledge score higher than the M4 and M5 non-EBM groups, but lower than the M5 EBM group. Conclusions Formal medical student training in EBM produced higher scores in attitudes, knowledge and self-reported critical appraisal skills compared with a randomized control group. Data from the concurrent groups add validity evidence to the study, but rigorous follow-up needs to be done to document retention of EBM abilities.
Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats
Susana González-Reyes,Silvia Guzmán-Beltrán,Omar Noel Medina-Campos,José Pedraza-Chaverri
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/801418
Abstract: Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatment of CGNs with 5–30?μM curcumin effectively increased by 2.3–4.9 fold heme oxygenase-1 (HO-1) expression and by 5.6–14.3-fold glutathione (GSH) levels. Moreover, 15?μM curcumin attenuated by 55% the increase in reactive oxygen species (ROS) production, by 94% the reduction of GSH/glutathione disulfide (GSSG) ratio, and by 49% the cell death induced by hemin. The inhibition of heme oxygenase system or GSH synthesis with tin mesoporphyrin and buthionine sulfoximine, respectively, suppressed the protective effect of curcumin against hemin-induced toxicity. These data strongly suggest that HO-1 and GSH play a major role in the protective effect of curcumin. Furthermore, it was found that 24?h of incubation with curcumin increases by 1.4-, 2.3-, and 5.2-fold the activity of glutathione reductase, glutathione S-transferase and superoxide dismutase, respectively. Additionally, it was found that curcumin was capable of inducing nuclear factor (erythroid-derived 2)-like 2 (Nrf2) translocation into the nucleus. These data suggest that the pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death. 1. Introduction The use of natural products has been a general approach for regulating antioxidant homeostasis in cells. Curcumin is a yellow polyphenol compound found in turmeric, derived from Curcuma longa Linn. [1]. Curcumin has shown to be an effective anticarcinogenic, antiviral, antioxidant [2–5], and anti-inflammatory substance in human, cell cultures and animal models [6, 7]. Curcumin acts as a direct and an indirect antioxidant since it scavenges reactive oxygen and nitrogen species [8, 9] and induces cytoprotective enzymes such as glutathione-S-transferase (GST), γ-glutamyl cysteine ligase (γ-GCL), heme oxygenase-1 (HO-1), among others [10, 11]. Curcumin is able to scavenge hydrogen peroxide, peroxyl radicals, superoxide anion, hydroxyl radicals, singlet oxygen, nitric oxide, and peroxynitrite anion [8]. It has been shown that curcumin induces endogenous antioxidant defense mechanisms by modulating transcription factors such as nuclear factor (erythroid-derived 2)-like 2 (Nrf2) [4], activator protein-1 (AP-1), and nuclear
High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes
Yolanda Gonzalez, M Teresa Herrera, Gloria Soldevila, Lourdes Garcia-Garcia, Guadalupe Fabián, E Martha Pérez-Armendariz, Karen Bobadilla, Silvia Guzmán-Beltrán, Eduardo Sada, Martha Torres
BMC Immunology , 2012, DOI: 10.1186/1471-2172-13-19
Abstract: CD33 expression was significantly decreased in monocytes from patients with type 2 diabetes, and higher levels of TNF-α, IL-8 and IL-12p70 were detected in the plasma of patients compared to healthy donors. Under high glucose conditions, CD33 protein and mRNA expression was significantly decreased, whereas spontaneous TNF-α secretion and SOCS-3 mRNA expression were increased in monocytes from healthy donors. Furthermore, the down-regulation of CD33 and increase in TNF-α production were prevented when monocytes were treated with the antioxidant α-tocopherol and cultured under high glucose conditions.Our results suggest that hyperglycemia down-regulates CD33 expression and triggers the spontaneous secretion of TNF-α by peripheral monocytes. This phenomenon involves the generation of ROS and the up-regulation of SOCS-3. These observations support the importance of blood glucose control for maintaining innate immune function and suggest the participation of CD33 in the inflammatory profile associated with type 2 diabetes.Both acute and chronic hyperglycemia are associated with inflammation [1]. Patients with newly diagnosed or established diabetes mellitus (DM) have significantly higher levels of acute-phase proteins and pro-inflammatory cytokines compared to control subjects without DM [2-5]. Monocytes isolated from patients with type 1 diabetes produce increased levels of IL-6, IL-1β and chemokines of the CXC family including IL-8 and interferon gamma-induced protein 10 (IP-10) [6]. Furthermore, monocytes from patients with DM produce higher levels of TNF-α and IL-8 in comparison to control monocytes [7-9].TNF-α production is thought to play a role in the generation of microvascular complications associated with diabetes, e.g., by enhancing chronic eye inflammation [10,11]. In addition to triggering acute and chronic inflammation, TNF-α regulates glucose and lipid metabolism and inhibits insulin production in pancreatic beta cells [12]. TNF-α is also produced in adipo
A framework for the construction of academic communities
Granados Beltrán,Carlo;
Folios , 2009,
Abstract: this article aims to explain how an academic community can be constructed based on teaching and research. for this purpose, first of all, a definition of academic community is provided; secondly, the way in which the building of this community can be done by fostering cooperative work, reflective teaching and teacher autonomy is described. in addition, the means by which students can take more active participation in this construction by engaging in critical thinking, learner autonomy and the implementation of a curriculum as inquiry are explained. finally, some tasks for the academic community are specified as well as its impact on the institutions and on the field of language teaching
Una visión sociológica del derecho de familia en Colombia. Radicalismo-1945
Beltrán Cristancho,Mauricio;
Estudios Socio-Jurídicos , 2008,
Abstract: this paper affirms that the economic and political failure of the radical period provided opportunities for those who proposed regeneration as a means of defending authority. family law became an important tool in that process. during the period studied by this article, the equality clause remained in colombian constitutions without any practical affect for the majority of the people. discrimination was imposed through family law over those who had born outside of a catholic marriage and/or had not previously legitimized their union through a catholic ceremony. by the middle of the 20th century, the dramatic situation of the nation?s children led to efforts to change the social prejudices through legislation, that is, in the same way the prejudices had been imposed.
Estar críticamente enfermo significa no ser capaz y no poder decidir
Beltrán Salazar,Oscar;
Index de Enfermería , 2008, DOI: 10.4321/S1132-12962008000200003
Abstract: objective: to describe the meaning for the critically sick patients hospitalized in icu of the experience of being dependent of nurses for meting needs. methodology: phenomenological focused research carried out in medellín in 2006; it included nine adults among 24 and 80 years who were critically sick and hospitalized in icu. the interview in depth was used for gathering information. the data were analyzed according to the outline proposed by cohen, kahan and steeves. results: the dependency on other people to act and decide, the suffering and the pain influence in the hardness of the experience of suffering a serious illness. discussion: not to be capable of meeting the own necessities and making decisions make the experience of suffering a serious illness "hard and difficult". conclusion: the dependence of patients with a serious illness should not be assumed by nurses but rather it should be evaluated in each case, as the same as the responses to this dependence to assure the respect for sick people′ rights.
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