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La costa del río Paraná: cultura, naturaleza y territorio
Bertuzzi,María Laura;
Apuntes: Revista de Estudios sobre Patrimonio Cultural - Journal of Cultural Heritage Studies , 2009,
Abstract: this article proposes the reconsideration of the notion of landscape and cultural landscape departing from a contemporary perspective and a concrete case: a fragment of the fluvial coast of paraná river. this area has historically been displaced from the provincial interest, becoming a periphery in terms of production and communication, despite its magnificent environmental conditions. the paper begins with the theoretical concept of cultural landscape and proposes its review using bibliography and cases of intervention. it also proposes new layers of interpretation based on differential characteristics that rise from the knowledge of the place and the need for new planning and acting tools. finally, and like a laboratory experience, a concrete action is presented, taking into account the activities of institutions and non governmental organizations, which could be replicated in other territorial segments. the article is based on the author's research and on her phd thesis.
Ochratoxin A and Aflatoxins in Liquorice Products
Amedeo Pietri,Silvia Rastelli,Terenzio Bertuzzi
Toxins , 2010, DOI: 10.3390/toxins2040758
Abstract: The occurrence of ochratoxin A (OTA) and aflatoxins (AFs) in liquorice products made in Italy was surveyed. Twenty-eight samples of dried liquorice extract and fifty-four of liquorice confectionery (liquorice content between 2 and 10%) were collected from retail outlets located in northern Italy. After extraction and purification through an immunoaffinity column, OTA and AFs were analysed using both HPLC-FLD and HPLC-MS/MS. OTA occurred in all samples of dried liquorice extract and in 61% of samples of liquorice confectionery, showing very high values for the former (mean 89.6 μg kg-1, maximum value 990.1 μg kg-1), and relatively low levels for the latter (mean 0.96 μg kg-1, maximum value 8.3 μg kg-1). The contribution of dried liquorice extract to OTA intake appears to be non-negligible for children, who are potentially high consumers. AF contamination resulted very low: AFB1 was detected only in 15.8% of samples (maximum value 7.7 μg kg-1, mean 0.38 and 0.41 μg kg-1 for dried liquorice extract and liquorice confectionery, respectively); the other AFs were not detected. To our knowledge, it is the first time that AFB1 has been detected in liquorice extract samples.
La sepsis como estresor: asociación con los niveles séricos de cortisol, proteína C reactiva e interleuquina1beta
Gaydou,Luisa; Bertuzzi,Romina; Moretti,Edgardo;
Acta bioqu?-mica cl?-nica latinoamericana , 2009,
Abstract: stress has a high prevalence in the world; one of its causes is sepsis. during this syndrome, cytokines are released, which activate the hypothalamic - pituitary - adrenal (hpa) axis. this raises cortisol levels and acute phase proteins. the goal of this work was to analize the effects of sepsis on the hpa axis, through cortisol measurements, and to associate it with interleukin 1 beta (il1-b) and c reactive protein (crp). cortisol was measured by electrochemoluminiscence, crp by immunoturbidimetric method and il1-b by elisa in sera of septic (s, n=40) and non septic (ns, n=21) patients. cortisol was significantly higher than its cut-off (co), established by roc curves, in 63% of s patients, and only in 14% of ns (or: 10,0; ci: 2.5 - 39.7; p<0.05). crp was elevated in 55% of s, and in 43% of ns (p>0.05). in some s patients, very high levels of il1-b were observed on the day of admission. the joint elevation of crp and cortisol was of 40% in s and 5% in ns, while rises in all parameters were only seen in s (8%). it can be concluded that in the group of patients studied sepsis acted as an activator of the hpa axis, as evidenced by the elevated cortisol levels.
La sepsis como estresor: asociación con los niveles séricos de cortisol, proteína C reactiva e interleuquina1beta Sepsis as a stressor: association with serum levels of cortisol, C reactive protein and interleukin 1beta
Luisa Gaydou,Romina Bertuzzi,Edgardo Moretti
Acta bioqu?-mica cl?-nica latinoamericana , 2009,
Abstract: El estrés tiene alta prevalencia en el mundo; una de sus causas es la sepsis. Durante la misma, se liberan citoquinas que activan el eje hipotálamo-hipofiso suprarrenal (HHS) elevándose el cortisol y proteínas de fase aguda. El objetivo de este trabajo fue analizar el efecto de la sepsis sobre el eje HHS a través del cortisol, y asociarlo con interleuquina 1 beta (IL1-beta) y proteína C reactiva (PCR). Se dosó cortisol por electroquimioluminscencia, PCR por inmunoturbidimetría e IL1-beta por ELISA en sueros de pacientes sépticos (S, n=40) y no sépticos (NS, n=21). El cortisol fue significativamente mayor al valor de corte (VC), establecido mediante curva ROC, en el 63% de pacientes S, y sólo en el 14% de NS (OR: 10,0; IC: 2,5 - 39,7; p<0,05). La PCR estuvo elevada en el 55% de S, y en el 43% de NS (p>0,05). En algunos pacientes S se evidenciaron niveles muy aumentados de IL1-beta en el día de admisión. La elevación conjunta de PCR y cortisol fue del 40% en S y del 5% en NS, mientras que el aumento de los tres parámetros sólo se vio en S (8%). En conclusión, en el grupo de pacientes estudiado la sepsis actuó como activador del eje HHS, evidenciado por el incremento en el cortisol. Stress has a high prevalence in the world; one of its causes is sepsis. During this syndrome, cytokines are released, which activate the hypothalamic - pituitary - adrenal (HPA) axis. This raises cortisol levels and acute phase proteins. The goal of this work was to analize the effects of sepsis on the HPA axis, through cortisol measurements, and to associate it with interleukin 1 beta (IL1-beta) and C reactive protein (CRP). Cortisol was measured by electrochemoluminiscence, CRP by immunoturbidimetric method and IL1-beta by ELISA in sera of septic (S, n=40) and non septic (NS, n=21) patients. Cortisol was significantly higher than its cut-off (CO), established by ROC curves, in 63% of S patients, and only in 14% of NS (OR: 10,0; CI: 2.5 - 39.7; p<0.05). CRP was elevated in 55% of S, and in 43% of NS (p>0.05). In some S patients, very high levels of IL1-beta were observed on the day of admission. The joint elevation of CRP and cortisol was of 40% in S and 5% in NS, while rises in all parameters were only seen in S (8%). It can be concluded that in the group of patients studied sepsis acted as an activator of the HPA axis, as evidenced by the elevated cortisol levels.
Water barrier properties of starch-clay nanocomposite films
Slavutsky, Aníbal Marcelo;Bertuzzi, María Alejandra;Armada, Margarita;
Brazilian Journal of Food Technology , 2012, DOI: 10.1590/S1981-67232012005000014
Abstract: the functional properties of corn starch based films were improved by incorporating nanoclay (montmorillonite). nanoclay was incorporated in the polymer matrix using two different methodologies and the films were formed by casting. the effect of film preparation methodology and of the nanoclay concentration on the physicochemical properties of the films was studied. depending on film preparation method used, intercalated or exfoliated nanocomposite films were obtained. the ftir spectra showed a strong interaction between the montmorillonite and the starch molecules. opacity was dependent on the nanoclay dispersion method used. water vapor solubility and permeability decreased with increasing montmorillonite content and were affected by the dispersion method. water diffusion was only dependent on the nanoclay content due to the increase in tortuosity of the diffusion path, caused by the nanoparticles. the results showed that the incorporation of 5% of montmorillonite using an adequate dispersion method, improved the water resistance and barrier properties of corn starch based films. nanoparticles reduced the damage caused to the properties of these hydrophilic films by the increase in moisture content.
Mechanical properties of a high amylose content corn starch based film, gelatinized at low temperature
Bertuzzi, Maria Alejandra;Gottifredi, Juan Carlos;Armada, Margarita;
Brazilian Journal of Food Technology , 2012, DOI: 10.1590/S1981-67232012005000015
Abstract: in the present study, a better knowledge of the influence of plasticizer content, storage relative humidity and film thickness on the mechanical properties of high amylose corn starch based films gelatinized at low temperature, is presented. the mechanical properties, tensile strength and percentage of elongation at break of high amylose corn starch films plasticized with glycerol were evaluated using tension tests. the films exhibited an increase in elongation and a decrease in tensile strength with increasing plasticizer concentration. when the glycerol level was high, some fissures were detected in the dry films, possible due to phase separation (starch-glycerol) phenomena. film crystallinity is related to the reorganization capacity of the polymer chain, and thus the relative film crystallinity should increase with plasticizer content (glycerol and water). the mechanical properties were found to be strongly dependent on the water content due to the hydrophilic nature of starch films. the influence of moisture sorption on tensile strength was similar to that of plasticization with glycerol. the relationship between polymer chain mobility and water content explained this behavior. elongation suffered a different effect and maximum values were reached at 45% relative humidity. the final drop in elongation was due to a softening of the structure at high relative humidity. the thicker the film the longer the drying time required, leading to greater relative crystallinity due to the corresponding increase in the possibility for chain reorganization. as a consequence, linear increases in tensile strength and elongation were observed with film thickness over the whole range studied (30 to 100 μm).
Arranjos e rede de apoio familiar de idosos que vivem em uma área rural
Bertuzzi, Daiane;Paskulin, Lisiane Girardi Manganelli;Morais, Eliane Pinheiro de;
Texto & Contexto - Enfermagem , 2012, DOI: 10.1590/S0104-07072012000100018
Abstract: this study identifies different family arrangements and describes the family support network for elderly who live in the brazilian countryside. this transverse study was accomplished with thirty-six elderly through domicile interviews. study results show a greater number of women (80.6%) among the elderly living in good living conditions with good household income. the most common family arrangement found out was tri-generational (50%), in which these elderly, their children, and their grandchildren all live together. the study observed a two-way process in informal transfers among these elderly, heads of the family, and other relatives living with the elderly. in families where the elderly was not the head of the household, the son usually takes up this role. in these families, the elderly receive more assistance than they provide, with the opposite occurring in families in which the elderly are the head. these results point toward the need for implementing new care actions for the rural elderly and their families which present difficulty in accessing brazilian health care services.
Arranjos e rede de apoio familiar de idosos que vivem em uma área rural
Daiane Bertuzzi,Lisiane Girardi Manganelli Paskulin,Eliane Pinheiro de Morais
Texto & Contexto - Enfermagem , 2012,
Abstract: Este estudio identifica los diferentes arreglos de vivienda, describe la red de apoyo familiar de los ancianos que viven en una zona rural. Es un estudo transversal, realizado com 36 ancianos, a través de entrevistas em el hogar. Los resultados mostraron un mayor número de mujeres (80,6%) en adultos mayores, con buenas condiciones de vivienda y ingreso. La disposición de la familia más común fue trigenerational (50%), con domicilio en las personas mayores, hijos y nietos. Hubo un proceso de doble vía de las transferencias informales entre los jefes de hogar mayores y otros familiares que viven con las personas mayores. En las familias donde los ancianos no es el jefe de familia, los ancianos reciben más ayuda que ellos proporcionan, mientras que lo contrario ocurrió en las familias donde la persona mayor es el jefe. Este estudo permite acciones para la población rural de edad avanzada y sus famílias.
First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation
Piccaluga PP,Paolini S,Bertuzzi C,De Leo A
Journal of Blood Medicine , 2012,
Abstract: Pier Paolo Piccaluga,* Stefania Paolini,* Clara Bertuzzi, Antonio De Leo, Gianantonio RostiHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, "L and A Seràgnoli", S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy*These authors contributed equally to this workAbstract: The therapeutic landscape of chronic myeloid leukemia (CML) has changed dramatically in the last decade. In particular, the availability of imatinib mesylate, a tyrosine kinase inhibitor targeting BCR-ABL, has led to profound and durable remissions in the majority of patients. However, a couple of issues have emerged and partially obscured this scenario. First, it has become clear that a significant proportion of patients either present with primary resistance to imatinib or develop secondary resistance sooner or later during treatment. Second, although the drug is generally well tolerated, a percentage of patients eventually cease treatment because of toxicity. Bearing this in mind, second-generation tyrosine kinase inhibitors have been introduced, including nilotinib. Phase I and II studies indicate remarkable activity for this compound in CML cases resistant to imatinib, including some of those carrying BCR-ABL1 mutants. More recently, two Phase II studies and a III randomized Phase clinical trial demonstrated the superiority of nilotinib compared with imatinib in terms of complete cytogenetic and major molecular responses, which are two relevant surrogate measures of long-term survival in CML. In this paper, we review the most relevant data on nilotinib as first-line treatment for CML, and discuss the rationale for its routine use, as well as some possible future perspectives for CML patients.Keywords: chronic myeloid leukemia, nilotinib, targeted therapy, BCR-ABL1
Excretion pattern of aflatoxins in buffalo milk and carry-over in mozzarella cheese
A. Pietri,T. Bertuzzi,P. Fortunati,A. Gualla
Italian Journal of Animal Science , 2011, DOI: 10.4081/ijas.2003.s1.302
Abstract: Some raw materials, used in animal feeding, can be contaminated by aflatoxins (AF). All the mammals that ingest AFB1, excrete small amounts of the hydroxylated metabolite aflatoxin M1 (AFM1) in their milk (Wood 1991). In the case of cow’s milk, the percentage excreted is 1-3% of that ingested (Veldman et al. 1992). AFM1 has been categorised as a class 2B, possible human carcinogen. AFM1 is associated with the protein fraction of milk and hence it is carried-over to cheese and to other milk products (Brackett and Marth, 1982)....
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