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Reasons for Prophylactic Mastectomy in Women Carrying BRCA 1/2 Mutation: A Systematic Literature Review  [PDF]
Manuel Machado, Sofia Braga
Advances in Breast Cancer Research (ABCR) , 2013, DOI: 10.4236/abcr.2013.23017
Abstract:

Although the majority of breast cancers are sporadic, it is estimated that between 5% and 10% of cases are hereditary and mostly associated with BRCA 1 and BRCA 2 mutations. Women with BRCA 1 or BRCA 2 mutation present up to 95% increased risk of breast cancer and are advised to take preventive measures. Surveillance, chemoprevention and prophylactic surgery (mastectomy and oophorectomy) are risk-reducing strategies. This literature review aims to respond to two major questions: 1) to what extent is the decision-making for prophylactic mastectomy in women with the BRCA mutation a more relevant option than other strategies, and 2) what are the major factors influencing the decision for mastectomy? For this purpose, 27 published articles were reviewed. Results show: a) the decision for mastectomy is more frequent in women carrying BRCA 1/2 mutation than in non-carriers; mastectomy being less frequent than oophorectomy; b) the decision-making is significantly associated with BRCA mutation, parity, age and family history; c) reasons underlying women decision-making relate to anxiety toward the risk of cancer, concerns with surgery, body-image and sexuality. It is discussed that, due to the complexity of the decision-making process, these cases require a careful and meticulous approach regarding information provided, and in addressing concerns.

Media??es institucionais e inova??es metodológicas: a teoria da regula??o e a formaliza??o da dinamica econ?mica histórica
Braga, Ruy;
Sociedade e Estado , 2002, DOI: 10.1590/S0102-69922002000200010
Abstract: the aim of this article is to analyze the relationships between methodological innovations and fordism in the so called "parisian" regulation school. therefore we describe the progressive changes that took place on its original research project, underlining the regulationist's methodological sense: the heterodox research theory development focused on social mediations analysis and based in an anti-reductionist methodology of social institutions.
MMBB arquitectos
Braga,Milton;
ARQ (Santiago) , 2002, DOI: 10.4067/S0717-69962002005100009
Abstract: they emerge from a country whose 20th century architectural project was charged with a certain modernity, marked by the presence of le corbusier, niemeyer and the creation of brasilia. today, the neutral nature of the works of mmbb architects marks a transition, offering silence as a possible route to the new brazil
A tatuagem como gênero: uma vis?o discursiva
Braga, Sandro;
Linguagem em (Dis)curso , 2009, DOI: 10.1590/S1518-76322009000100007
Abstract: this article presents a reading perspective of the semiotic material which is constitutive of tattoos as a discursive genre. in order to do so, based on the bakhtinian theoretical framework on speech genres, an interface is established with the french discourse analysis trend
RELATIVE INVARIANCE FOR MONOID ACTIONS
BRAGA,CARLOS;
Proyecciones (Antofagasta) , 2001, DOI: 10.4067/S0716-09172001000300002
Abstract: let s be a topological monoid acting on the topological space m. let j be a subset of m. our purpose here is to study the subsets of m which correspond, under the action of s, to the relative (with respect to j) invariant control sets for control systems (see [4] section 3.3). the relation x y if y 2 cl(sx) and x 2 cl(sy) is an equivalence relation and the classes with respect to this relation with nonempty interior in m are the control sets for the action of s. it is given conditions for the existence and uniqueness of relative invariant classes. as it was done for the control sets, we define an order in the classes and relate it to the relative invariant classes. we also show under certain condition that the relative invariant classes are relatively closed in j
Uma sociologia da condi??o proletária contemporanea
Braga, Ruy;
Tempo Social , 2006, DOI: 10.1590/S0103-20702006000100008
Abstract: the increase in company outsourcing over the last two decades has led to the development of a new type of worker on the margins of the productive system: the call centre operator. responsible for a wide range of information services, the rapid expansion in call centres has stirred the interest of a number of researchers in different areas of knowledge. analyzing the work of the call centre operator, the article looks to deepen our comprehension of the sea-change currently affecting today's working class. in contrast to what many forecasted some fifteen years ago, the information revolution has failed to dissolve the opposition between manual and mental work activities: instead, it has served as a key instrument for controlling and routinizing intellectual work. in turning to this theme, we explore some of the insights into the contemporary working class condition found in the inspirational study by stéphane beaud and michel pialoux on the peugeot car assembly plant in sochaux-montbéliard.
Urmuz, précurseur de l’Avant-garde roumaine
Corin Braga
Synergies Roumanie , 2007,
Abstract: Urmuz est considéré par les historiens contemporains de la littérature comme le précurseur de l’Avant-garde roumaine. Dans l’article, l’auteur essaye de faire une psychocritique de la littérature d’Urmuz, de cerner les mécanismes psychanalytiques qui pourraient expliquer la paralogique de ses récits.
MMBB arquitectos
Milton Braga
ARQ , 2002,
Abstract: Viniendo de un país que generó durante el siglo XX un proyecto arquitectónico cargado de una cierta modernidad y te ido por la presencia de Le Corbusier, Niemeyer y la construcción de Brasilia, la neutralidad de la obra de MMBB arquitectos se constituye como una transición hacia el Brasil actual, planteando el silencio como un camino posible They emerge from a country whose 20th century architectural project was charged with a certain modernity, marked by the presence of Le Corbusier, Niemeyer and the creation of Brasilia. Today, the neutral nature of the works of MMBB Architects marks a transition, offering silence as a possible route to the new Brazil
Norman Manea et les univers concentrationnaires
Corin Braga
Synergies Roumanie , 2010,
Abstract: Norman Manea est un écrivain roumain, prosateur et romancier, naturalisé aux Etats-Unis. Ses livres, traduits dans plus de vingt langues, s’apparentent par leur vision et leur thématique à ceux de Herta Müller, écrivain allemand d’origine roumaine, lauréate du prix Nobel en 2009, reflétant la persécution de l’individu sous un régime totalitaire. Juif roumain, Norman Manea a subi deux univers concentrationnaires qui se sont succédé en Roumanie au XXe siècle, le fascisme, pendant la deuxième guerre mondiale, et le communisme, instauré après l’invasion soviétique. Cette étude analyse le mode de transfiguration esthétique des traumas biographiques présentés dans quelques-uns des romans les plus connus de Norman Manea, Octombrie, ora opt (1981), Plicul negru (1986), Despre clovni (1997).
A tatuagem como gênero: uma vis o discursiva
Sandro Braga
Linguagem em (Dis)curso , 2009,
Abstract: Este ensaio apresenta uma perspectiva de leitura do material semiótico constitutivo da tatuagem como um gênero discursivo. Para isso, parte-se do arcabou o teórico bakhtiniano acerca dos gêneros do discurso, estabelecendo uma interface com a Análise do Discurso de corrente francesa.
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