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OALib Journal期刊

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Sobre la inconsistencia teórica del positivismo incluyente1
Orunesu,Claudina;
An??lisis filos?3fico , 2007,
Abstract: professor juan carlos bayón has argued that inclusive legal positivism should be rejected because its plausibility depends on the idea of a social convention to follow nonconventional criteria of validity. in his view, if there were agreement on the content of these criteria, it would be impossible to sustain its non-conventional character; and without agreement, there would not be a common social practice, and thus no social rule would exist. therefore, inclusive positivism faces a dilemma: being indistinguishable from exclusive positivism or not being a genuine form of conventionalism at all. this article evaluates a possible way out of this dilemma. it explores the different versions of inclusive legal positivism and its limits, and tries to build an opposing argument grounded on the scope of the conventionality thesis that would rescue inclusive legal positivism from the accusation of theoretical inconsistency.
SISTEM PENGENDALIAN KUALITAS DENGAN BANTUAN EXPERT SYSTEM UNTUK MENURUNKAN TINGKAT KECACATAN PRODUK (Studi Kasus di Perusahaan Pembuat Filaman Lampu)
Shelly Yuliana,Herry Christian Palit,Claudina Milawati
Jurnal Teknik Industri , 2005,
Abstract: The research discusses the quality control system in producing lamp filament. Meantime, the quality control system produces ahigh level of failure, 10-17%. The result of the identification revealed that the primary coil and double coil processes have the highest failure, ± 17%, and the main cause of rejection is the unflat coil. The research covers the development of attribute control chart (p chart), before and after implementations, development of control plans and documents needed, expert system program to investigate the root cause of the failure, proportional test and final result failure. The result of the implementation of suggestion, gives a significant decrease of failure and the average of failure level of the final product is average 5.74%. Abstract in Bahasa Indonesia : Penelitian ini membahas sistem pengendalian kualitas pada pembuatan lampu filamen. Sistem pengendalian kualitas yang berjalan sekarang menghasilkan kecacatan yang tinggi, 10-17%. Identifikasi yang telah dilakukan menunjukkan bahwa proses primary coil dan double coil memiliki tingkat kecacatan terbesar ± 17% dengan penyebab utama reject adalah coil tidak rata. Penelitian yang dilakukan meliputi pembuatan dan monitoring peta kendali atribut (p chart) baik awal dan akhir hasil implementasi usulan, pembuatan control plan, dokumen-dokumen terhadap pengendalian penyebab kecacatan utama, program expert system yang digunakan untuk penelusuran penyebab kecacatan, uji proporsi dan tingkat kecacatan akhir. Hasil implementasi usulan memberikan penurunan tingkat kecacatan yang signifikan terhadap penyebab kecacatan utama dan rata-rata tingkat kecacatan produk akhir sebesar 5,74%. Kata kunci: sistem pengendalian kualitas, expert system.
A DIMENS O HUMANA DO TRABALHO
Teresa Claudina de Oliveira Cunha,Vania Machado Seabra Puglia
Vértices , 2010,
Abstract: Em meio ao contexto de mudan a que se nos apresenta, é preciso trazer à reflex o as novas tendências do mundo do trabalho e a importancia de estabelecer uma nova estratégia de a o voltada para a valoriza o n o só do trabalho, mas também do profissional, em toda a sua plenitude de ser social.
Calidad microbiológica del agua utilizada en establecimientos lecheros de la zona de Villa María (Córdoba) Microbiological quality of the water used in a random sample from dairy farms in Córdoba, Argentina
Susana G. Bettera,Silvana A. Dieser,Claudina Vissio,Graciela Geuna
Revista argentina de microbiolog?-a , 2011,
Abstract: Se evaluó la calidad bacteriológica del agua de pozo y del agua de lavado en una muestra aleatoria de 50 tambos distribuidos en la cuenca lechera de Villa María (Córdoba), Argentina. La visita a los tambos se realizó en 2007. Un 46 % y un 24 % de los tambos presentaron recuentos de aerobios mesófilos superiores a 500 UFC/ml en el agua de lavado y en el agua de pozo, respectivamente. En un 20 % de los establecimientos se aisló Escherichia coli de ambas fuentes de agua. Pseudomonas aeruginosa registró una alta frecuencia de aislamiento en el agua de pozo (36 %) y en la de lavado (42 %). Un 80 % y un 88 % de los establecimientos contaban con agua de pozo y de lavado no aptas, respectivamente. Los niveles de mesófilos aerobios y de coliformes totales presentes en el agua de pozo mostraron una concordancia moderada con los detectados en el agua destinada al lavado. En virtud de estos resultados, puede afirmarse que un elevado porcentaje de los tambos ubicados en la cuenca lechera de Villa María emplean agua de calidad bacteriológica deficiente, no apta para el orde o ni el lavado de las instalaciones. Bacteriological contamination of well water and wash water in a random sample obtained from 50 farms from Villa María (Córdoba) dairy area, Argentina, was evaluated during a visit in 2007. Forty six percent and 24 % of farms showed an aerobic mesophilic bacteria count higher than 500 CFU/ml in wash water and well water, respectively. Escherichia coli was isolated in 20 % of samples from both sources. Pseudomonas aeruginosa showed high frequency of isolation in well water (36 %) and wash water (42 %). Eighty and eighty-eight percent of dairy farms have contaminated well water and wash water, respectively. The findings show moderate concordance between contamination of well water and wash water for mesophilic aerobics and total coliforms. The results reveal that a high percentage of dairy farms in the basin under study have poor bacteriological water quality, not suitable for milking and washing facilities.
Oxidative Stress in Alzheimer's and Parkinson's Diseases: Insights from the Yeast Saccharomyces cerevisiae
Catarina Pimentel,Liliana Batista-Nascimento,Claudina Rodrigues-Pousada,Regina A. Menezes
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/132146
Abstract: Alzheimer's (AD) and Parkinson's (PD) diseases are the two most common causes of dementia in aged population. Both are protein-misfolding diseases characterized by the presence of protein deposits in the brain. Despite growing evidence suggesting that oxidative stress is critical to neuronal death, its precise role in disease etiology and progression has not yet been fully understood. Budding yeast Saccharomyces cerevisiae shares conserved biological processes with all eukaryotic cells, including neurons. This fact together with the possibility of simple and quick genetic manipulation highlights this organism as a valuable tool to unravel complex and fundamental mechanisms underlying neurodegeneration. In this paper, we summarize the latest knowledge on the role of oxidative stress in neurodegenerative disorders, with emphasis on AD and PD. Additionally, we provide an overview of the work undertaken to study AD and PD in yeast, focusing the use of this model to understand the effect of oxidative stress in both diseases.
Iron and Neurodegeneration: From Cellular Homeostasis to Disease
Liliana Batista-Nascimento,Catarina Pimentel,Regina Andrade Menezes,Claudina Rodrigues-Pousada
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/128647
Abstract: Accumulation of iron (Fe) is often detected in the brains of people suffering from neurodegenerative diseases. High Fe concentrations have been consistently observed in Parkinson’s, Alzheimer’s, and Huntington’s diseases; however, it is not clear whether this Fe contributes to the progression of these diseases. Other conditions, such as Friedreich’s ataxia or neuroferritinopathy are associated with genetic factors that cause Fe misregulation. Consequently, excessive intracellular Fe increases oxidative stress, which leads to neuronal dysfunction and death. The characterization of the mechanisms involved in the misregulation of Fe in the brain is crucial to understand the pathology of the neurodegenerative disorders and develop new therapeutic strategies. Saccharomyces cerevisiae, as the best understood eukaryotic organism, has already begun to play a role in the neurological disorders; thus it could perhaps become a valuable tool also to study the metalloneurobiology.
The Role of the Yap5 Transcription Factor in Remodeling Gene Expression in Response to Fe Bioavailability
Catarina Pimentel, Cristina Vicente, Regina Andrade Menezes, Soraia Caetano, Laura Carreto, Claudina Rodrigues-Pousada
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037434
Abstract: The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.
Staphylococcus aureus and chronic airway disease
Lara Derycke, Claudina Pérez-Novo, Koen Van Crombruggen, Marie-No?lle Corriveau, Claus Bachert
World Allergy Organization Journal , 2010, DOI: 10.1097/wox.0b013e3181ecd8ae
Abstract:
Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
Claudina Pérez-Novo, Cindy Claeys, Paul Van Cauwenberge, Claus Bachert
Respiratory Research , 2006, DOI: 10.1186/1465-9921-7-75
Abstract: Samples were prepared from nasal tissue of patients with chronic rhinosinusitis without nasal polyps (CRS, n = 11), with nasal polyps (CRS-NP, n = 13) and healthy subjects (Controls, n = 6). mRNA expression of CysLT1, CysLT2, BLT1, BLT2, E-prostanoid receptors (EP1, EP2, EP3, EP4) and sol-IL-5Rα was determined by real-time PCR. Concentrations of PGE2, LTC4/D4/E4, LTB4 and sol-IL-5Rα were determined by ELISA and of ECP by ImmunoCap. Protein expression and tissue localization of eicosanoid receptors and activated eosinophils were evaluated by immunohistochemistry.CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls, and CRS compared to controls, whereas CysLT2 mRNA was enhanced in both CRS groups without differences between them. Levels of both receptors correlated to the number of activated eosinophils, sol-IL-5Rα, ECP and LTC4/D4/E4 concentrations in the disease groups. PGE2 protein concentrations and prostanoid receptors EP1 and EP3 were down-regulated in the CRS-NP tissue vs. CRS and controls, whereas EP2 and EP4 expression was enhanced in CRS and CRS-NP patients vs. controls. No differences in BLT receptors were observed between patients and controls.CyLTs receptors are up-regulated in nasal polyp tissue and their expression correlate with eosinophilic inflammation supporting previous results. Eicosanoid receptors mRNA pattern observed suggests that down-regulation of EP1 and EP3 in CRS-NP and up-regulation EP2 and EP4 in CRS and CRS-NP groups may have some role in the development of the diseases and their regulation may not be directly linked to eosinophil activation but involve post-transcriptional events mainly related to other inflammatory cell sources.The role of eicosanoids in the pathophysiology of chronic inflammatory airway diseases has been well documented; however, the key steps in the regulation leading to the production of these molecules remain unclear. Eicosanoid signalling pathway operates through lipid G-prote
Morfometría geométrica de Triatoma maculata (Erichson, 1848) de ambientes doméstico y peridoméstico, estado Lara, Venezuela
Soto Vivas,Ana; Rodríguez,Claudina; Bonfante-Cabarca,Rafael; Aldana,Elis;
Boletín de Malariología y Salud Ambiental , 2007,
Abstract: wing geometric morphometrics was used to study the spatial structuring of populations of triatoma maculata from different ecotopes within a village in western venezuela. a total of 74 t. maculata collected from peridomestic and domestic ecotopes from november 2002 to november 2003 were analyzed. no statistically significant differences were found between males and females from domestic and peridomestic ecotopes, which suggests that the triatomines collected form part of the same population and therefore non-adaptative strategies are being developed by t. maculata to human dwellings in this locality.
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