OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Isabel;” ,找到相关结果约8254条。
Clinical Study on Autosomal Dominant Polycystic Kidney Disease among South Indians  [PDF]
P. Veeramuthumari, W. Isabel
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.44035

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder in humans, with a frequency of 1 in 100 in the general population. ADPKD is caused by mutations in PKD1 gene (85%) located on human chromosome 16p13.3; Mutations in the PKD2 gene contribute to 15% of ADPKD incidence and is located on human chromosome 4q2-23. A total of hundred ADPKD patients and age and sex matched healthy individuals were selected for the study. The study was aimed to evaluate the prevalence of ADPKD, lipid profile and level of calcium (Ca), sodium (Na), iron (Fe) and potassium (K) in patients with ADPKD and in healthy individuals. The lipid profile was analyzed using commercially available span kit and semiautoanalyzer (Erba, Chem 5X). The Ca, Na, Fe and K concentrations were estimated by flame photometry (ELICO, CL 22D) and atomic absorption spectroscopy (ELICO, SL 173) and significant changes were noted at p < 0.05. The ADPKD patients were observed to have lipid abnormalities, hyponatremia, cholesterolemia, renal osteodystrophy, cardiovascular problems and anemia. Therefore, the study reveals an association between the lipid profile and Ca, Na, Fe and K levels with ADPKD among South Indian population.

Creating Locally Relevant Health Information
Isabel Carter
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020046
Drosophila TIEG Is a Modulator of Different Signalling Pathways Involved in Wing Patterning and Cell Proliferation
Isabel Rodriguez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018418
Abstract: Acquisition of a final shape and size during organ development requires a regulated program of growth and patterning controlled by a complex genetic network of signalling molecules that must be coordinated to provide positional information to each cell within the corresponding organ or tissue. The mechanism by which all these signals are coordinated to yield a final response is not well understood. Here, I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger proteins that belong to the Krüppel-like factor (KLF) family and were initially identified in human osteoblasts and pancreatic tumor cells for the ability to enhance TGF-β response. Using the developing wing of Drosophila as “in vivo” model, the dTIEG function has been studied in the control of cell proliferation and patterning. These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG also regulates the activity of JAK/STAT pathway suggesting a conserved role of TIEG proteins as positive regulators of TGF-β signalling and as mediators of the crosstalk between signalling pathways acting in a same cellular context.
Comentario a "Estética apofática y hermenéutica del misterio" de A. Vega
Cabrera, Isabel;
Diánoia , 2009,
Abstract: in this commentary four questions are put to amador vega; the first is about the difference between apophatic aesthetics and hermeneutics of mystery; the second concerns the kind of emotions involved in his apophatic aesthetics; the third is whether this kind of approach can be adequate for figurative art; and the last is about the role played by ritual (and repetition) in his religious aesthetics.
La religiosidad de Wittgenstein
Cabrera, Isabel;
Diánoia , 2008,
Abstract: this paper is divided into two parts. the first briefly gathers wittgenstein analysis of religious language to retake his idea that the meaning of religious terms has to be searched in practices and emotions. the second part applies this idea to wittgenstein's own writings about religion, to bring to light the images, emotions and practices that constituted the vital eco of his religious thinking.
The emergence of tropical medicine in Portugal: The School of Tropical Medicine and the Colonial Hospital of Lisbon (1902-1935)
Dynamis , 2008, DOI: 10.4321/S0211-95362008000100013
Abstract: the school of tropical medicine was founded in 1902 along with the colonial hospital of lisbon. the portuguese government recognized the importance of colonising the tropics and therefore supported the creation of a specific locus of medical training that would prove to be crucial to the clinical and experimental study of tropical diseases. this paper examines the importance of such institutions for the emergence of a new scientific area of research while also functioning as a consolidation factor for the third portuguese colonial empire. the creation of a new concept of medical practice with respect to tropical diseases characterizes a specific aspect of colonization: it underlies and drives the discourse of colonization itself. consultation of data collected by the portuguese tropical school and the colonial hospital during the period between 1902 and 1935, the starting point of the present study, seeks to shed light on the ongoing debate concerning the history of tropical medicine within european colonial discourse.
Ser?o explicáveis os conflitos violentos em áfrica: Notas de leitura
Finisterra - Revista Portuguesa de Geografia , 2010,
Abstract: after political independence - and especially in the context of accelerating globalisation that followed the end of the cold war -, most african countries have been affected by political instability, sometimes culminating in violent civil wars and massacres. in the current scientific debates, the wars of the 1990?s and 2000?s have been singled out and characterised by some authors as ?new wars?. however, there is considerable controversy surrounding this distinction between ?old? and ?new? wars. the causes of african conflicts are complex and multidimensional. from a conflict prevention and resolution perspective, it is essential that our understanding of african conflicts be improved through further analyses of the root causes of conflict, as well as of their complex and multiple interactions over time. this paper discusses some of the main doctrinal and theoretical perspectives on this topic, with particular reference to the cases of the sudan, c?te d?ivoire and uganda. the linkages between war, hunger and food insecurity, and gender relations are also examined, namely as regards the situation of women combatants.
Los restos de pingüinos (Spheniscidae) de los sitios de Cabo Blanco (Santa Cruz, Patagonia Argentina): Análisis tafonómico y perspectivas arqueológicas
Intersecciones en antropolog?-a , 2006,
Abstract: some properties of spheniscidae make them potentially very suitable for intensive exploitation by patagonian hunters: they are easy to hunt, have a higher economic yield than other birds in the region, and are spatially predictable during the long breeding season, when they remain on land. however, the archaeological record of the atlantic coast of patagonia suggests little or no exploitation at all of spheniscidae breeding colonies throughout the holocene. nonetheless, taphonomic observations in the region have provided indications that there is a high probability of archaeological materials found with modern bird remains. spheniscidae remains at sites in cabo blanco (santa cruz, argentina) are among the few bone assemblages of these birds that have been recovered in archaeological deposits from continental patagonia. a taphonomic analysis is presented here, aimed at assessing the integrity (sensu binford 1981) of these deposits. furthermore, the need for a rigorous estimation of all the agents and processes taking part in the formation of penguin bone assemblages in the region before attempting interpretations of past human behavior is examined.
Educa??o Histórica: vontades de mudan?a
Barca, Isabel;
Educar em Revista , 2011, DOI: 10.1590/S0104-40602011000500005
Abstract: to deeply explore the conceptions about historical change beyond presentist analyses some relevant epistemological debates among diversified views on the issue must be reminded. although some of them are now outofdate, they still have remained at a commonsense level. in the light of an intensive, permanently renovated historiographical production, open to different perspectives and foci, we might infer that, under a framework of multi perspectivism acknowledgement, change in history is conceived in a complex and problematic manner, with no fixed meaning or predetermined direction. in history education, the students' conceptions on change have been explored in some studies with fruitful clues for educational action. accordingly, in this paper the theoretical background, methods and results from those studies in several countries on students' ideas about change in history will be given. some of their implications are intended to contribute as clues to help developing a type of temporal orientation eventually more appropriate to these times of uncertainty we currently live in.
O séjour de D. Pedro I em Paris e a imprensa francesa: familiaridade e exotismo
Lustosa, Isabel;
História (S?o Paulo) , 2012, DOI: 10.1590/S0101-90742012000200009
Abstract: the image of d. pedro i in the french press during the period he lived in paris (august 1831 to january 1832) was essential to the success he has achieved in seeking support for the expedition to retake the crown with d. d. maria ii usurped by miguel. thanks to the efforts of scholars from brazil, a considerable amount of information about the country has already circulated in europe. to the liberal character who d. pedro gave the brazilian political model that would guarantee the support of the french liberals, joined mythical aspects of his career and the country where he lived. the familiarity with d. pedro attended all, nobles and commoners would also be an important factor for achieving membership to the cause of d. maria.

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