Background: Several Phase III randomized trials have demonstrated
improved local control and survival for post-mastectomy radiotherapy in
patients with high-risk pathologic features. Close or involved surgical margins
were not included as high-risk in these protocols, but have been associated
with increased risk of local failure; however, the impact of a boost dose
following chestwall radiotherapy in this setting remains to be determined.
Methods: Retrospective single-institution outcomes analysis for patients with
close or involved surgical margins treated with post-operative radiotherapy is followed by a boost. Results: Between 2003 and 2011, 34 patients were
identified for inclusion in the present study. The median chestwall dose was
5040 cGy (range 5000 - 5040) and median
boost dose was 1080 cGy (900 - 1620). At a median
follow-up of 38.4 months (10.2 - 115.6; with 29%
more than 5 years), 28 patients were alive without evidence of recurrence, 3
were alive with recurrent disease (1 chestwall), and 3 had died (none with recurrent
disease). The 3-year local control, disease-free survival, and overall
survivals were 96.9%, 93.9%, and 93.1%, respectively. Conclusion: Chestwall radiotherapy plus boost
results in low risk of early locoregional recurrence for women with close or
involved surgical margin(s) at mastectomy. Further investigation of PMRT with
or without boost in this setting is warranted.
Inhibitory compounds are often found to be the leading cause of anaerobic reactor upset and failure since they are present in substantial concentration in wastewaters and organic solid wastes. Among these inhibitory compounds, organic compounds are mentioned and more especially aromatic compounds. The purpose of this work was to evaluate the effect of bisubstituted aromatics functional groups on the methanogenic inhibition. The toxicity to acetoclastic methanogenic bacteria has performed in serum flasks, utilizing digested pig manure as inoculums, by measuring cumulative methane production. The results obtained indicate that some general relationships exist between the bisubstituted aromatic structures and their inhibitory effects on methanogenic bacteria. This demonstrates sufficiently that the grafting of hydrophobic or hydrophilic substituent on the benzene or monofunctional aromatic compound, make the obtained compound more or less toxic as the case and that in the same order of toxicity. A significant correlation was obtained indicating that the partitioning of bisubstituted aromatics into lipophilic membranes in bacteria may have a role in the inhibition of methane biosynthesis.