oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

4 ( 1 )

3 ( 1 )

2018 ( 582 )

2017 ( 841 )

自定义范围…

匹配条件: “Maria A. Annunziato” ,找到相关结果约522143条。
列表显示的所有文章,均可免费获取
第1页/共522143条
每页显示
Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*  [PDF]
Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104366
Abstract:
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two sequences (2 × 2) with a 7-day washout period between each dose in 28 healthy volunteers. Subjects were randomly assigned to each of the administration sequences. The pharmacokinetic parameters evaluated were: Cmax, AUC0-t and AUC0-∞. For the bioequivalence analysis, the AUC0-t was calculated from the time of administration to the 12th hour, posology requested for the medication test, by the trapezoidal method; Software: Excel. The means and Confidence Intervals were compared between 80% - 125% for the quotient of Cmax, Tmax, AUC0-t and AUC0-∞. Results: Cmax 8.3529 ± 1.9176 μg/mL vs. 7.7175 ± 2.1751 μg/mL, Tmax 0.75 h vs. 1.25 h, AUC0-12 25.9560 ± 4.9846 μg/mL/hr vs. 24.9015 ± 5.1507 μg/mL/ hr and AUC0-∞ 27.0147 ± 5.1099 μg/mL/hr vs. 25.6400 ± 5.1144 μg/mL/h, respectively. 95% IC: Cmax 106.26% - 107.85%, AUC0-12 101.11% - 101.78% and AUC0-∞ 100.53% - 102.94%. Conclusion: The test formulation Ketoprofen 150 mg LP, manufactured by LETI S.A.V. Laboratories, is bioequivalent with respect to the reference product ProfenidBI 150 mg controlled release tablets, manufactured by Sanofi-Aventis Pharmaceuticals LTDA Laboratories, as the Values obtained from AUC and Cmax were maintained in the range of 80% - 125%.
SEA LEVEL SIGNALS CORRECTION FOR THE 2011 TOHOKU TSUNAMI
A. Annunziato
Science of Tsunami Hazards , 2012,
Abstract: The paper analyses the signals measured during the M9.0 Tohoku Tsunami in order to identify the effect of the subsidence on the measurements and to determine correction factors to be applied to the measurements. The objective is to have a coherent set of measurements that can allow the correct estimation of the source term for this event through inversion techniques. In fact the inversion techniques tend to minimize the difference between the measured signals and the calculated value; which means that in the initial period and also for the peak, the solution found without considering this correction tends to get higher values of the source (the peak in some cases is almost 1.4 m higher on a maximum of 4-5 m, thus is not negligible).The amount of the correction has been determined using the long-term displacement shown in the measurements; the subsidence estimates are also compared with the values obtained using GPS instruments. The analysis shows that the subsidence has a notable influence on the measurements where the deformation is large and that taking into account the deformation in the signals may improve the quality of the estimation of the initial deformation.
Ultrastructural Findings, at Micrometric and Nanometric Scales, in Rectal and Muscular Mucosa of Patients with HIV/AIDS and Anorectal Pathology  [PDF]
Annunziato Maria Antonieta, Sardi?as Carlos, Finol Hector, Carvajal Ana, González Roschman, De Gouveia Yetsenia, García Estefanie, Garibaldi Liseth
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.95041
Abstract: Objective: To determine the ultrastructural findings on Rectal Mucosa (RM) of patients with HIV/AIDS and anorectal pathologies (ARP), at micrometric and nanometric scales. Materials and methods: 5 patients were evaluated, 18 - 55 years old, with ARP (HIV co-infection with HPV, n = 4, and HIV-negative patient with HPV infection) (control n = 1), who were referred to the Coloproctology Unit of the HUC, and subjected to rectoscopy and biopsy. RM samples were identified, placed in a sterile plastic bottle with 1 mL of 2% glutaraldehyde and immediately transported for routine processing of fine cut (60 - 90 nm) to be evaluated via Transmission Electron Microscopy (TEM). They were fixed with Karnovsky solution with Millonig phosphate buffer (pH 7.4 and 320 mOsm) and post-fixed with OsO4 under the same conditions of pH and osmolarity. Results: Ultrastructural findings, at 106 scale: 1) Intestinal mucosa: vacuoles of mucus of different sizes that seem to be fused. 2) Smooth muscle cells: loss of definition of contractile myofilaments mass. 3) Unmyelinated axons and terminals of Schwann cells (SC): Edema and loss of their plasma membranes in some areas of association with axon terminals as well as abundant collagen fibers associated with SC. Ultrastructural findings, at 109 scale: 1) Smooth muscle cells: folded wrapper cores and edema of mitochondria and rough endoplasmic reticulum cisterns (RER). 2) Myelinated axon terminals: Loss of synaptic vesicles. 3) Fibroblasts: One observes mitochondria and cisterns of RER with alterations. All these alterations can generate intestinal and anorectal dysfunction in these patients. Conclusions: The HIV causes changes in rectal and muscular mucosa despite HAART treatment with undetectable viral load.
Web-based Tsunami Early Warning System: a case study of the 2010 Kepulaunan Mentawai Earthquake and Tsunami
E. Ulutas,A. Inan,A. Annunziato
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2012, DOI: 10.5194/nhess-12-1855-2012
Abstract: This study analyzes the response of the Global Disasters Alerts and Coordination System (GDACS) in relation to a case study: the Kepulaunan Mentawai earthquake and related tsunami, which occurred on 25 October 2010. The GDACS, developed by the European Commission Joint Research Center, combines existing web-based disaster information management systems with the aim to alert the international community in case of major disasters. The tsunami simulation system is an integral part of the GDACS. In more detail, the study aims to assess the tsunami hazard on the Mentawai and Sumatra coasts: the tsunami heights and arrival times have been estimated employing three propagation models based on the long wave theory. The analysis was performed in three stages: (1) pre-calculated simulations by using the tsunami scenario database for that region, used by the GDACS system to estimate the alert level; (2) near-real-time simulated tsunami forecasts, automatically performed by the GDACS system whenever a new earthquake is detected by the seismological data providers; and (3) post-event tsunami calculations using GCMT (Global Centroid Moment Tensor) fault mechanism solutions proposed by US Geological Survey (USGS) for this event. The GDACS system estimates the alert level based on the first type of calculations and on that basis sends alert messages to its users; the second type of calculations is available within 30–40 min after the notification of the event but does not change the estimated alert level. The third type of calculations is performed to improve the initial estimations and to have a better understanding of the extent of the possible damage. The automatic alert level for the earthquake was given between Green and Orange Alert, which, in the logic of GDACS, means no need or moderate need of international humanitarian assistance; however, the earthquake generated 3 to 9 m tsunami run-up along southwestern coasts of the Pagai Islands where 431 people died. The post-event calculations indicated medium-high humanitarian impacts.
Tsunamigenic earthquakes in the Gulf of Cadiz: fault model and recurrence
L. M. Matias,T. Cunha,A. Annunziato,M. A. Baptista
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2013, DOI: 10.5194/nhess-13-1-2013
Abstract: The Gulf of Cadiz, as part of the Azores-Gibraltar plate boundary, is recognized as a potential source of big earthquakes and tsunamis that may affect the bordering countries, as occurred on 1 November 1755. Preparing for the future, Portugal is establishing a national tsunami warning system in which the threat caused by any large-magnitude earthquake in the area is estimated from a comprehensive database of scenarios. In this paper we summarize the knowledge about the active tectonics in the Gulf of Cadiz and integrate the available seismological information in order to propose the generation model of destructive tsunamis to be applied in tsunami warnings. The fault model derived is then used to estimate the recurrence of large earthquakes using the fault slip rates obtained by Cunha et al. (2012) from thin-sheet neotectonic modelling. Finally we evaluate the consistency of seismicity rates derived from historical and instrumental catalogues with the convergence rates between Eurasia and Nubia given by plate kinematic models.
THE TSUNAMI ASSESSMENT MODELLING SYSTEM BY THE JOINT RESEARCH CENTRE
Alessandro Annunziato
Science of Tsunami Hazards , 2007,
Abstract: The Tsunami Assessment Modeling System was developed by the European Commission, Joint Research Centre, in order to serve Tsunami early warning systems such as the Global Disaster Alerts and Coordination System (GDACS) in the evaluation of possible consequences by a Tsunami of seismic nature. The Tsunami Assessment Modeling System is currently operational and is calculating in real time all the events occurring in the world, calculating the expected Tsunami wave height and identifying the locations where the wave height should be too high. The first part of the paper describes the structure of the system, the underlying analytical models and the informatics arrangement; the second part shows the activation of the system and the results of the calculated analyses. The final part shows future development of this modeling tool.
A finite difference method for Piecewise Deterministic Processes with memory
Mario Annunziato
Mathematics , 2006,
Abstract: In this paper the numerical approximation of solutions of Liouville-Master Equations for time-dependent distribution functions of Piecewise Deterministic Processes with memory is considered. These equations are linear hyperbolic PDEs with non-constant coefficients, and boundary conditions that depend on integrals over the interior of the integration domain. We construct a finite difference method of the first order, by a combination of the upwind method, for PDEs, and by a direct quadrature, for the boundary condition. We analyse convergence of the numerical solution for distribution functions evolving towards an equilibrium. Numerical results for two problems, whose analytical solutions are known in closed form, illustrate the theoretical finding.
A finite difference method for piecewise deterministic Markov processes
Mario Annunziato
Mathematics , 2006,
Abstract: An extension of non-deterministic processes driven by the random telegraph signal is introduced in the framework of "piecewise deterministic Markov processes" [Davis], including a broader category of random systems. The corresponding Liouville-Master Equation is established and the upwind method is applied to numerical calculation of the distribution function. The convergence of the numerical solution is proved under an appropriate Courant-Friedrichs-Lewy condition. The same condition preserve the non-decreasing property of the calculated distribution function. Some numerical tests are presented.
Efficacy and Safety Evaluation of Sildenafil Citrate in the Form of 50 mg Orodispersible Tablets Controlled by Placebo  [PDF]
Maria Antonieta Annunziato, Di Capua Teodoro, Dieguez Vicente, Ledos Luis, Koury Mufid
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.73023
Abstract: Purpose: To evaluate the efficacy and safety of sildenafil in orodispersable tablets of 50 mg vs. placebo in men with erectile dysfunction (ED). Methods: A blind, comparative, placebo controlled, randomized study was developed in 106 patients with ED. They randomly received sildenafil orodispersable 50 mg (Group I) or placebo (Group II) 3 times per week, 1 hour before sexual activity, during 4 weeks. The efficacy was evaluated by IIEF-5 and the adverse events (AE) by poll. Results: After 4 weeks a percentage improvement of the ED was observed in Group I patients 44% of whom became without ED vs. 2% of Group II, with an additional statistical significant improvement evidenced respect to the placebo in the IIEF-5 score from 13.7 ± 4.9 to 19.9 ± 4.4 vs. 13.1 ± 4.0 to 17.8 ± 4.9 in the placebo group, Confidence Interval (CI95%): 19.90 vs. 13.98, respectively, p < 0.001. Regarding the basal value, a total increment of the IIEF-5 was observed, at the end of the 4 weeks treatment of 60% in Group I vs. 10% in Group II. In Group I was evidenced an statistical significant improvement of the IIEF-5 in each of the 5 questions at the end of the 4 weeks, specially in questions 3, 4, and 5 related to keeping the erection and satisfaction (p < 0.0001). The AE were mild, transient and could be tolerated. No patient dropped out because AE. Conclusions: Sildenafil was superior to placebo, substantially improved the IIEF-5 scores, showing a statistical significant therapeutic response in the ED treatment and it was safe and well tolerated.
The LOBI Integral System Test Facility Experimental Programme
Carmelo Addabbo,Alessandro Annunziato
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/238019
Abstract: The LOBI project has been carried out in the framework of the European Commission Reactor Safety Research Programme in close collaboration with institutional and/or industrial research organizations of EC member countries. The primary objective of the research programme was the generation of an experimental data base for the assessment of the predictive capabilities of thermal-hydraulic system codes used in pressurised water reactor safety analysis. Within this context, experiments have been conducted in the LOBI integral system test facility designed, constructed, and operated (1979–1991) at the Ispra Site of the Joint Research Centre. This paper provides a historical perspective and summarizes major achievements of the research programme which has represented an effective approach to international collaboration in the field of reactor safety research and development. Emphasis is also placed on knowledge management aspects of the acquired experimental data base and on related online open access/retrieval user functionalities.
第1页/共522143条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.