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PENTALOGíA DE CANTRELL EN UN RECIéN NACIDO EXPUESTO EN úTERO A MISOPROSTOL
Pachajoa,Harry;
Revista chilena de obstetricia y ginecología , 2010, DOI: 10.4067/S0717-75262010000100007
Abstract: misoprostol is a synthetic analogue of prostaglandin e1 and is used for effects such as uterotonic aborti-facient. in countries where abortion is used as unsuccessful in the first trimester of gestation, reported a spectrum of congenital malformations associated with prenatal exposure, which include moebius syndrome, abdominal wall defects, and anomalies as artrogriposis reduction members, among others. the pentalogy of cantrell with a prevalence of 1 in 65,000 live births, is a syndrome consisting of 5 abnormalities: a defect in the abdominal wall, lower sternal defect, defect above the diaphragm, diaphragmatic pericardial defect, and congenital abnormalities of the heart. we report a case of pentalogy of cantrell associated with the use of misoprostol in the first trimester of pregnancy, this report is the first record of this association.
Pentalogía de Cantrell en el primer gemelo de un embarazo gemelar monocigótico: presentación de un caso y revisión de la literatura
Pachajoa,Harry;
Revista Colombiana de Obstetricia y Ginecología , 2011,
Abstract: introduction: cantrell's pentalogy (cp) consists of five anomalies: upper abdominal wall defects, lower sternal defects, anterior diaphragmatic defects, diaphragmatic pericardial defects and abnormalities of the heart. around 250 cases have been reported; only 6 have involved twins and 4 of these have described discordance of such anomaly. objective: presenting a case of twin pregnancy-associated cp and literature review regarding such association, emphasizing prenatal diagnosis and etiology. materials and methods: a case of cantrell’s pentalogy is presented which only affected the first twin from a monozygotic twin pregnancy. information was sought in scielo and pubmed databases, using the following mesh terminology "pentalogy of cantrell", "twin" and "pentalogía de cantrell" and "gemelar" in spanish. conclusion: cp may be ecographically suspected by ectopia cordis and thoracoabdominal defects. the presentation of a case in twin pregnancy is an extremely rare association.
Pentalogía de Cantrell en el primer gemelo de un embarazo gemelar monocigótico: presentación de un caso y revisión de la literatura Cantrell's pentalogy in the first twin from a monozygotic twin pregnancy: a case presentation and literature review
Harry Pachajoa
Revista Colombiana de Obstetricia y Ginecología , 2011,
Abstract: Introducción: la Pentalogía de Cantrell (PC) se compone de cinco anomalías: defecto superior de pared abdominal, defecto esternal inferior, defecto diafragmáticoanterior,defectopericárdicodiafragmático y anormalidades del corazón. Cerca de 250 casos han sido reportados, solo 6 involucran gemelos, y de estos 4 describen discordancia de esta anomalía. Objetivo: realizar la presentación de un caso de PC asociado a embarazo gemelar y la revisión de la literatura de esta asociación con énfasis en el diagnóstico prenatal y la etiología. Materiales y métodos: se presenta un caso de Pentalogía de Cantrell que afecta solo al primer gemelo de un embarazo gemelar monocigótico, se realizó una búsqueda de la información en las bases de datos SciELO y PubMed con la terminología MeSH "Pentalogy of Cantrel", "twin" y en espa ol "Pentalogía de Cantrell" y "gemelar". Conclusión: la PC puede ser sospechada ecográficamente por ectopia cordis y defecto toracoabdominal. La presentación de un caso en un embarazo gemelar es una asociación poco frecuente. Introduction: Cantrell's pentalogy (CP) consists of five anomalies: upper abdominal wall defects, lower sternal defects, anterior diaphragmatic defects, diaphragmatic pericardial defects and abnormalities of the heart. Around 250 cases have been reported; only 6 have involved twins and 4 of these have described discordance of such anomaly. Objective: presenting a case of twin pregnancy-associated CP and literature review regarding such association, emphasizing prenatal diagnosis and etiology. Materials and methods: a case of Cantrell’s pentalogy is presented which only affected the first twin from a monozygotic twin pregnancy. Information was sought in SciELO and PubMed databases, using the following MeSH terminology "Pentalogy of Cantrell", "Twin" and "Pentalogía de Cantrell" and "gemelar" in Spanish. Conclusion: CP may be ecographically suspected by ectopia cordis and thoracoabdominal defects. The presentation of a case in twin pregnancy is an extremely rare association.
PENTALOGíA DE CANTRELL EN UN RECIéN NACIDO EXPUESTO EN úTERO A MISOPROSTOL
Harry Pachajoa
Revista Chilena de Obstetricia y Ginecología , 2010,
Abstract: El misoprostol es un análogo sintético de la prostaglandina E1 y es usada por sus efectos utero-tónicos como abortivo. En los países donde se utiliza como abortivo sin éxito durante el primer trimestre de gestación, se han informado un espectro de malformaciones congenitas asociadas con la exposición prenatal, que incluyen el síndrome de Moebius, defectos de la pared abdominal, artrogriposis y anomalías por reducción de los miembros, entre otros. La pentalogía de Cantrell (PC), con una prevalencia de 1 en 65.000 nacidos vivos, es un síndrome polimalformativo que consta de 5 anomalías: un defecto de la pared abdominal, defecto esternal inferior, defecto del diafragma anterior, defecto pericárdico diafragmático y anormalidades congenitas del corazón. Se reporta un caso de pentalogía de Cantrell asociado al uso de misoprostol en el primer trimestre de la gestación, siendo este reporte el primer registro de esta asociación. Misoprostol is a synthetic analogue of prostaglandin E1 and is used for effects such as uterotonic aborti-facient. In countries where abortion is used as unsuccessful in the first trimester of gestation, reported a spectrum of congenital malformations associated with prenatal exposure, which include Moebius syndrome, abdominal wall defects, and anomalies as artrogriposis reduction members, among others. The pentalogy of Cantrell with a prevalence of 1 in 65,000 live births, is a syndrome consisting of 5 abnormalities: a defect in the abdominal wall, lower sternal defect, defect above the diaphragm, diaphragmatic pericardial defect, and congenital abnormalities of the heart. We report a case of Pentalogy of Cantrell associated with the use of misoprostol in the first trimester of pregnancy, this report is the first record of this association.
Carta al editor
Harry Pachajoa
CIMEL. Ciencia e Investigación Médica Estudiantil Latinoamericana , 2006,
Abstract:
Carta al editor
Harry Pachajoa
Colombia Médica , 2012,
Abstract: Recently, Valencia et al., published a very interesting article called Lipid profile in a group of patients with Turner’s syndrome at Clínica Universitaria Bolivariana in the city of Medellín between 2000 and 2009". An article which evaluated lipid levels in patients withTurner syndrome in a Colombian clinic, the study associated results of lipid profile with karyotype and other risk factors for coronary heart disease.
Embriopatía por isotretinoína con microtia-anotia y cardiopatía: Presentación de un caso
Pachajoa,Harry; Ordo?ez,Adriana;
Archivos argentinos de pediatr?-a , 2012,
Abstract: la isotretinoína es un retinoide derivado de la vitamina a utilizado para el tratamiento del acné noduloquístico y refractario, pero ha sido catalogado como un medicamento teratogénico. se ha comunicado un espectro de defectos congénitos que incluyen malformaciones craneofaciales, defectos cardíacos y defectos en el sistema nervioso con la exposición prenatal a este medicamento. se presenta el caso de una recién nacida con antecedente de exposición prenatal a isotretinoína con defectos congénitos craneofaciales que incluyen parálisis facial, anotia derecha y microtia izquierda, y cardiopatía compleja.
Cutis verticis gyrata
Paula M. Hurtado,Harry Pachajoa
Medicina (Buenos Aires) , 2012,
Abstract:
Use of 3D Multislide CT in the Study of a Fetus with Cyclopia
Pachajoa,Harry; Vejarano,Luis Eduardo; Isaza,Carolina;
International Journal of Morphology , 2012, DOI: 10.4067/S0717-95022012000100015
Abstract: cyclopia is a rare congenital malformation incompatible with life; it is characterized by the presence of a single eye in the center position, secondary to alobar holoprosencephaly. cyclopia etiology is heterogeneous, with a prevalence of 1.05 in 100,000 births. we report a case of cyclopia with sinoftalmía in a fetus of 21 weeks where they use 3d multislice computed tomography as a complementary study.
18p-syndrome: Presentation of two cases with alobar holoprosencenphaly
Pachajoa,Harry; Saldarriaga,Wilmar; Isaza,Carolina;
Colombia Médica , 2010,
Abstract: introduction: the syndrome by deletion of the short arm of chromosome 18 is an infrequent syndrome, and its phenotypical variability makes it difficult to recognize. its most frequently observed clinical characteristics include mental retardation, growth retardation, craniofacial malformations, including long ears, microcephaly and short neck; other less frequent associated malformations include holoprosencephaly. case report: we present two patients with deletion of the short arm of chromosome 18, one presented a de novo mutation and the other was produced by a balanced translocation 6p/18p of maternal origin. both patients presented alobar holoprosencephaly and cebocephaly, low-frequency clinical characteristics in this syndrome. discussion: alobar holoprosencephaly is a malformation appearing in 10% of patients with deletion of the short arm of chromosome 18; we review the probable physiopathology of holoprosencephaly in this syndrome.
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