OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Rasoazanakolona Voahanginirina” ,找到相关结果约2条。
Influence of the Use of Capsaicin on the Storage of Rice Grain  [PDF]
Rasoazanakolona Voahanginirina
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104833
The storage of milled rice requires monitoring to achieve the goal promoted for its consumption: preserving the quality to feed effectively. Sometimes, however, contamination infiltrates under an atmosphere favoring the formation of weevils. A futile loss is created by the unexpected degradation. The effect of capsaicin on whitened rice Sitophilus o. weevils was monitored over time based on four different factors: the presence of chilli, the initial number of weevils present or introduced into milled rice, the weight of rice processed, and the variety of rice. The number of surviving weevils has been determined for up to six months. The Kruskall-Wallis test was performed on 34 samples of five varieties of milled rice. This showed a significant effect of chilli capsaicin action regardless of the factors considered. There are varieties of rice that respond well to treatment with capsaicin. Our experimentation proved that these are the varieties forming a high number of weevils at the beginning. The action of chilli capsaicin was also verified as an insect repellent and unappetizing, especially at the initial time that allowed to see leaking insects. It does not prevent the hatching of larvae, even if it has the capacity to kill weevils. The observed facts show that capsaicin is reserved for the protection of samples of whitened milled rice still devoid of contamination of larvae or adult weevils.
Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway
Karin Hadas, Voahanginirina Randriamboavonjy, Amro Elgheznawy, Alexander Mann, Ingrid Fleming
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074401
Abstract: Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases. Since many of the deleterious effects of glucose have been attributed to its metabolite methylgyloxal (MG) rather than to hyperglycemia itself, the aim of the present study was to characterize the effects of MG on platelet function. Washed human platelets were pre-incubated for 15 min with MG and platelet aggregation, adhesion on matrix-coated slides and signaling (Western blot) were assessed ex vivo. In vivo, the effect of MG on thrombus formation was determined using the FeCl3-induced carotid artery injury model. MG potentiated thrombin-induced platelet aggregation and dense granule release, but inhibited platelet spreading on fibronectin and collagen. In vivo, MG accelerated thrombus formation but decreased thrombus stability. At the molecular level, MG increased intracellular Ca2+ and activated classical PKCs at the same time as inhibiting PI3K/Akt and the β3-integrin outside-in signaling. In conclusion, these findings indicate that the enhanced MG concentration measured in diabetic patients can directly contribute to the platelet dysfunction associated with diabetes characterized by hyperaggregability and reduced thrombus stability.

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