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Lutero y la política
Simiele,Javier;
Enfoques , 2010,
Abstract: this paper discusses the relationship between martin luther's theology and his political stances. first, the author describes the theoretical frame used. then some opinions and attitudes about the reformation are reviewed, as expressed by various experts and, specifically, by some of the classic authors in the sociological field. then the lutheran theory is presented, taking special consideration of the thoughts and thinkers that influenced its origins. finally, the augustine monk's political stances are put forward as the author discusses their degree of influence on some of the modern political ideas.
Enfermedad de Erdheim-Chester e histiocitosis de células de Langerhans: ?Una asociación fortuita?
Simiele Narvarte,A.; Novoa Sanjurjo,F.; Gómez Rodríguez,N.; Antón Badiola,I.;
Anales de Medicina Interna , 2004, DOI: 10.4321/S0212-71992004001200006
Abstract: erdheim-chester disease is an idiopathic systemic histiocytosis hystologically different to langerhans histiocytosis which is characterized by symmetric sclerotic bone lesions, predominantly affecting the diaphyseal and metaphyseal areas of large bones. it is not classified within malignant histicytosis, but the clinical course tends to be agressive with a poor reponse to different schedules of treatment. in rare cases the association of both entities has been reported: erdheim-chester disease and langerhans histiocytosis. we present a new case with histological data of both histiocytosis whose clinical course included bone and muscle pain, insipidus diabetes, exophthalmos, bilateral symmetrical sclerosing bone lesions and a cerebellar syndrome.
Compromiso epidural espinal como presentación de los linfomas no hodgkinianos: aportación de 6 casos
Simiele Narvarte,A.; Gómez Rodríguez,N.; Novoa Sanjurjo,F.;
Anales de Medicina Interna , 2003, DOI: 10.4321/S0212-71992003000900005
Abstract: spinal cord compression and radicular involvement are infrequent events in the natural history of non-hodgkin?s lymphoma, which usually are secondary to invasion of spinal extradural space, and rarely are the presenting manifestations of this condition. thoracic segment is predominantly affected, but any spinal region can be affected. histologically, the spinal tumour are frequently a high-grade b lymphoma with aggressive behaviour. the aim of this work was to describe six new cases of non-hodgkin?s lymphoma in adults (five woman and one men), presenting with spinal neurological complications. the medical literature about this entity are revised.
Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies
Antonino Grassadonia,Pasquale Cioffi,Felice Simiele,Laura Iezzi,Marinella Zilli,Clara Natoli
Cancers , 2013, DOI: 10.3390/cancers5030919
Abstract: Hydroxamate-based histone deacetylase inhibitors (Hb-HDACIs), such as vorinostat, belinostat and panobinostat, have been previously shown to have a wide range of activity in hematologic malignancies such as cutaneous T-cell lymphoma and multiple myeloma. Recent data show that they synergize with a variety of cytotoxic and molecular targeted agents in many different solid tumors, including breast, prostate, pancreatic, lung and ovarian cancer. Hb-HDACIs have a quite good toxicity profile and are now being tested in phase I and II clinical trials in solid tumors with promising results in selected neoplasms, such as hepatocarcinoma. This review will focus on their clinical activity and safety in patients with advanced solid neoplasms.
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