oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

匹配条件: “Takehara” ,找到相关结果约49条。
列表显示的所有文章,均可免费获取
第1页/共49条
每页显示
Component-Oriented Reliability Analysis Based on Hierarchical Bayesian Model for an Open Source Software  [PDF]
Yoshinobu Tamura, Hidemitsu Takehara, Shigeru Yamada
American Journal of Operations Research (AJOR) , 2011, DOI: 10.4236/ajor.2011.12004
Abstract: The successful experience of adopting distributed development models in such open source projects includes GNU/Linux operating system, Apache HTTP server, Android, BusyBox, and so on. The open source project contains special features so-called software composition by which several geographically-dispersed compo-nents are developed in all parts of the world. We propose a method of component-oriented reliability as-sessment based on hierarchical Bayesian model and Markov chain Monte Carlo methods. Especially, we fo-cus on the fault-detection rate for each component reported to the bug tracking system. We can assess the reliability for the whole open source software system by using the confidence interval for each component. Also, we analyze actual software fault-count data to show numerical examples of reliability assessment for OSS.
Corporate Financing, Taxation, and Tobin’s q: Evidence from Japanese Firms and Industries  [PDF]
Keiichi Kubota, Susumu Saito, Hitoshi Takehara
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.33A004
Abstract:

This paper addresses the question of how taxation affects the cost of capital of firms and value of firms as measured by Tobin’s q. We construct a Real Business Cycle model and derive our original unlevered q on an after-tax basis, by removing financial tax shield effects in order to disentangle real operating profitability of firms and their financing decisions. Our model is an extended version of the two-sector general equilibrium model originally developed by Christiano and Fisher [1] and can incorporate both corporate and individual taxation. The unlevered q-value is derived from our general equilibrium solutions and some comparative static results are demonstrated with model predictions. In an empirical section of the paper, we find that the data support these model predictions, and thus they rationalize the use of our unlevered q. Our result possesses important policy implications for financial managers of the firms in correctly identifying firms’ true profitability aside from corporate tax shields as well as for the tax authority in changing the regulatory corporate tax rates.

The Development of S-Equol Diastereoisomer Specific ELISA  [PDF]
Takayuki Minekawa, Akira Kambegawa, Kumiko Shindome, Shizuka Takehara, Hidetoshi Arakawa
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.36059
Abstract: Equol is a metabolite of soybean isoflavone, daidzein, and many health benefits are expected. Endogenous equol in urine is S-equol and mostly exists as glucuronate or sulfate conjugate. In this study we preliminary established the simple enzyme-linked immunosorbent assay (ELISA) without deconjugation, then developed the S-equol specific ELISA involves deconjugation showing high stereospecificity to S-equol without using stereospecific antibody. For the simple ELISA, we used a polyclonal antibody that targets the regions not influenced by inhibition by conjugation of glucuronate and sulfate and achieved the correlation coefficient; r = 0.975, but the value was 30 % lower than high performance liquid chromatography (HPLC). Developing upon this we invented the specific ELISA established from S-equol homogeneous combination for the standard and enzyme-labeled antigen to enhance stereospecificity. The correlation with HPLC was favorable: r = 0.986, y = 0.996x – 6. Compared to the previous method using (R,S)-equol combination, cross-reactivity with R-equol was reduced from 65 to 13 %, and that with daidzein from 0.31% to 0.08%, markedly increased in the specificity. This study is expected to be applied for both simple clinical researches, and stereospecific immunoassays in which specific antibody preparation is difficult.
Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer
Kiyoto Takehara,Hideki Aoki,Yuko Takehara,Rie Yamasaki
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i38.5479
Abstract: Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diagnosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.
Efecto de los probióticos sobre el colesterol plasmático: Ensayo clínico controlado aleatorizado
Dalto,Paula; Takehara,Natalia Andrea;
Diaeta , 2012,
Abstract: objective: to determine whether the average drop in total cholesterol and ldl-cholesterol is higher in adult patients diagnosed with hypercholesterolemia who receive an hypocholesterolemic diet combined with a probiotic compared with those who receive only diet. materials and methods: a randomized controlled clinical trial. the sample consisted of 46 patients of both sexes who attended the pi?ero hospital outpatient center with a diagnosis of hypercholesterolemia from august 2009 to april 2011. they were assigned to two groups: one received an hypocholesterolemic diet and another the same diet plus a dairy product containing probiotic lactobacillus casei strain shirota. results: no significant differences were found in the average drop in total cholesterol between the group that followed the hypocholesterolemic diet and the one that followed the same diet combined with the probiotic (p = 0.386), whereas a significant difference (p <0.001) was observed between the initial and final total cholesterol in both. in the case of ldlcholesterol, no significant differences were found in its average drop between both groups (p = 0.313) as well, but there was a significant difference (p <0.001) between the initial and final ldl . conclusions: in this study no significant differences were found in the average drop in total cholesterol and ldl-cholesterol between the group that followed only the hypocholesterolemic diet and the group that followed the diet with the probiotic. however, the results obtained confirm that the adoption of a meal plan designed to achieve a reduction in total cholesterol and ldl-cholesterol is effective, becoming a mainstay for the prevention and treatment of cardiovascular diseases.
Efecto de los probióticos sobre el colesterol plasmático: Ensayo clínico controlado aleatorizado Effect of probiotics on plasma cholesterol: Randomized controlled clinical trial
Paula Dalto,Natalia Andrea Takehara
Diaeta , 2012,
Abstract: Objetivo: Determinar si la disminución promedio del colesterol total y LDL- colesterol es mayor en pacientes adultos con diagnóstico de hipercolesterolemia que reciben una dieta hipocolesterolémica sumada a un probiótico en comparación con aquellos que reciben sólo dieta. Materiales y métodos: Ensayo clínico controlado y aleatorizado. La muestra estuvo conformada por 46 pacientes de ambos sexos que asistieron a los consultorios externos del Hospital Pi ero con diagnóstico de hipercolesterolemia durante los meses de Agosto de 2009 a Abril de 2011. Los mismos fueron asignados a dos grupos: uno que recibió una dieta hipocolesterolémica y otro la misma dieta sumada a un producto lácteo que contiene la cepa probiótica Lactobacillus Casei Shirota. Resultados: En el caso del colesterol total no se hallaron diferencias significativas en el promedio de descenso del mismo entre el grupo que realizó la dieta hipocolesterolémica y el que realizó la misma dieta sumada al consumo del probiótico (p=0,386), al mismo tiempo que sí se pudo observar una diferencia significativa (p<0,001) entre el colesterol total inicial y el final en ambos. En lo que respecta al LDL-colesterol tampoco se hallaron diferencias significativas en el promedio de descenso del mismo entre ambos grupos (p=0,313), aunque hubo una diferencia significativa (p<0,001) entre el LDL-colesterol inicial y el final. Conclusiones: En este estudio no se han encontrado diferencias significativas en el descenso promedio del colesterol total y el LDL-colesterol en el grupo que realizó la dieta hipocolesterolémica sola en comparación con el que realizó la dieta y consumió el probiótico. Sin embargo, los resultados obtenidos permiten confirmar que la adopción de un plan alimentario destinado a lograr la reducción de los niveles de colesterol total y LDL- colesterol resulta efectivo, constituyéndose en un pilar fundamental para la prevención y tratamiento de las enfermedades cardiovasculares. Objective: To determine whether the average drop in total cholesterol and LDL-cholesterol is higher in adult patients diagnosed with hypercholesterolemia who receive an hypocholesterolemic diet combined with a probiotic compared with those who receive only diet. Materials and methods: A randomized controlled clinical trial. The sample consisted of 46 patients of both sexes who attended the Pi ero Hospital outpatient center with a diagnosis of hypercholesterolemia from August 2009 to April 2011. They were assigned to two groups: one received an hypocholesterolemic diet and another the same diet plus a dairy product containing
Physicians' communication skills with patients and legal liability in decided medical malpractice litigation cases in Japan
Tomoko Hamasaki, Tadamichi Takehara, Akihito Hagihara
BMC Family Practice , 2008, DOI: 10.1186/1471-2296-9-43
Abstract: Decisions of medical malpractice litigation cases between 1988 and 2005 in Japan, the pivotal issue of which was a physician's explanation, were analyzed in the study. The content of each decision was summarized using the study variables (information about the patient, doctor, manner of the doctor's explanation, and subsequent litigation), and a database comprising the content of each decision (N = 100) was constructed. In order to evaluate an association between doctors' communication skills with patients and the outcome of the litigation, the analysis was performed based on the outcome of litigation or the type of medical facility.The ratio of acknowledged physician liability by court decision was lower in cases in which the doctor's explanation occurred before treatment or surgery (p = 0.013). The ratio of acknowledged physician liability by court decision was higher in cases of elective or non-urgent treatment (p = 0.046). The ratio of acknowledged physician liability by court decision was higher in clinics than in hospital groups (p = 0.036).These findings are beneficial for the prevention of medical disputes and improvement of patient-physician communication.In recent years, it has become evident that doctors' explanations to patients and patients' understanding of these explanations in medical settings are associated with broader factors. The doctor's explanation and the patient's understanding of this explanation have been shown to influence patient satisfaction and adherence to medical regimen [1-3]. Along with an increase in the number of medical malpractice litigations in recent years, factors potentially responsible for the incidence of medical disputes have been explored. As of today, poor communication skills with patients by physicians are the main cause of medical disputes [4-8]. Thus, we can safely say that doctors' communication skills with patients are extremely important for the prevention of medical disputes, as well as for patient satisfaction.
A novel visual test for hydrogen sulfide on the tongue dorsum  [PDF]
Takashi Kanehira, Hirohisa Hongo, Junji Takehara, Kozo Asano, Kazumi Osada, Hiroshi Izumi, Yoshihiro Fujii, Wataru Sakamoto
Open Journal of Stomatology (OJST) , 2012, DOI: 10.4236/ojst.2012.24054
Abstract: Objective: The purpose of this study was to develop a novel colorimetric system for direct detection of hydrogen sulfide on the tongue dorsum from subjects with complaints of halitosis. Method: An assay system comprised of a cotton swab impregnated with zinc sulfate, attached chromatography paper, stabilizing solution, and coloring reagents for the methylene blue technique was developed. Using this system we investigated on the visualization of the hydrogen sulfide on the solid phase and possibility for evaluating the origin of oral malodor on the tongue dorsum. Results: The assay system made possible visualization of a linear curve ranging from 5.3 ng to 85 ng of hydrogen sulfide, with low reagent consumption and miniaturization. However, the sensitivity was different for gaseous and fluid samples. The biofilm of the tongue dorsum from subjects with complaints of halitosis showed different shades of methylene blue depending on the concentration of hydrogen sulfide. A positive correlation was found between hydrogen sulfide on the tongue dorsum and the concentration of VSC hydrogen sulfide in mouth breath as measured using an Oral Chroma semiconductor gas sensor. Conclusion: The results of this study suggest that the novel assay system can be used as a visual warning sensor for halitosis by measuring hydrogen sulfide on the tongue dorsum.
Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach
Kenichi Nakajima,Shinro Matsuo,Minoru Hasegawa,Seigo Kinuya,Kazuhiko Takehara
International Journal of Rheumatology , 2010, DOI: 10.1155/2010/496509
Abstract: Myocardial involvement is an important prognostic factor in patients with systemic sclerosis, and early diagnosis and staging of the disease have been sought after. Since myocardial damage is characterized by connective tissue disease, including fibrosis and diffuse vascular lesions or microcirculation, nuclear myocardial perfusion imaging has been a promising option for evaluating myocardial damages in early stages. In addition to the conventional stress-rest perfusion imaging, the current use of quantitative electrocardiographic gated imaging has contributed to more precise evaluation of cardiac perfusion, ventricular wall motion, and diastolic function, all of which have enhanced diagnostic ability of evaluating myocardial dysfunction. Abnormal sympathetic imaging with Iodine-123 metaiodobenzylguanidine might be another option for identifying myocardial damage. This paper deals with approaches from nuclear cardiology to detect perfusion and functional abnormality as an early sign of myocardial involvement as well as possible prognostic values in patients with abnormal imaging results. The role of nuclear cardiology in the era of multiple imaging modalities is discussed. 1. Introduction Systemic sclerosis (SSc) is a connective tissue disease characterized by diffuse vascular lesions and fibrosis, and it systemically involves various organs such as skin (scleroderma), heart, lung, kidney and gastrointestinal tracts [1–6]. Of these organ involvements, cardiac complications include arrhythmias, pericarditis, angina pectoris, congestive heart failure and sudden death. Autopsy findings demonstrated that myocardial fibrosis in SSc has been a common occurrence [1, 7]. Thus, it has become evident that early diagnosis and accurate staging of visceral involvement are fundamental for appropriate management and therapeutic approaches for SSc [8]. These approaches may provide a significant prognostic value to systemic sclerosis. Although the precise mechanism for pathogenesis and etiology is not the aim of this article, nuclear medicine approaches to SSc patients are presented in this paper. The mechanisms of cardiac dysfunction and insight that can be gained from nuclear imaging are discussed. 2. Subsets of SSc and Organ Involvements SSc is usually classified into two subsets of diffuse and limited cutaneous types (dcSSc and lcSSc) [3]. The major findings of skin sclerosis and organ involvement are summarized in Table 1. Common manifestations of organ involvement in dcSSc include interstitial lung disease, renal failure, diffuse gastrointestinal disease, and
Persistence of Avian Influenza Viruses in Various Artificially Frozen Environmental Water Types
Dany Shoham,Alam Jahangir,Sakchai Ruenphet,Kazuaki Takehara
Influenza Research and Treatment , 2012, DOI: 10.1155/2012/912326
Abstract: Background. This study investigates the viable persistence of avian influenza viruses (AIVs) in various types of artificially frozen environmental water and evaluates the feasibility of similar occurrence taking place in nature, and allowing for prolonged abiotic virus survival, with subsequent biotic viral recirculation. Methods. Fresh, brackish, and salty water, taken in Japan from aquatic biotopes regularly visited by migratory waterfowl, were seeded with AIVs. We monthly monitored the viability of the seeded viruses in the frozen state at ?20°C and ?30°C, for 12 months. We also monitored virus viability following repeatedly induced freezing and thawing. Results. The viruses exhibited considerable viable persistence all along that period of time, as well as during freezing-thawing cycles. Appreciable, yet noncrucial variances were observed in relation to some of the parameters examined. Conclusions. As typical waterborne pathogens of numerous northerly aquatic birds, AIVs are innately adapted to both the body temperature of their hosts (40°C to 42°C) and, presumably, to subzero temperatures of frozen lakes (down to ?54°C in parts of Siberia) occupied and virus-seeded by subclinically infected birds, prior to freezing. Marked cryostability of AIVs appears to be evident. Preservation in environmental ice has significant ecophylogenetic and epidemiological implications, potentially, and could account for various unexplained phenomena. 1. Background A wide diversity of bacteria, protozoa, and viruses are known to exist in various water bodies worldwide, including ponds, lakes, seas, and oceans [1]. In arctic and sub-arctic regions, those water bodies are frozen, entirely or partially, for 4 months (in the southern Taiga) up to 10 months (in the northern Tundra and Arctic Ocean), annually, in the form of seasonal ice. In the Arctic, perennial ice is found too across the Arctic Ocean and freshwater bodies located in Greenland and islands of the Arctic Ocean. All those water bodies are abundantly visited by migratory aquatic birds whenever partially or completely thawed. Consequently, microorganisms that are shed through feces by the birds into water become waterborne, until contracted again by a host or entrapped within refreezing water. In the case of viruses, as obligatory parasites, they are otherwise apt to perish, sooner or later; hence, whenever entrapped in ice, their cryotolerance might constitute a critical factor, in terms of persisting viability, meaning infectivity. The higher their cryotolerance, the longer is the period of time they are
第1页/共49条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.