oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

2018 ( 108 )

2017 ( 321 )

2016 ( 414 )

2015 ( 6453 )

自定义范围…

匹配条件: “Thara K. Simon” ,找到相关结果约147541条。
列表显示的所有文章,均可免费获取
第1页/共147541条
每页显示
Central Mucoepidermoid carcinoma of mandible – A case report and review of the literature
Deepti Simon, Thara Somanathan, K Ramdas, Manoj Pandey
World Journal of Surgical Oncology , 2003, DOI: 10.1186/1477-7819-1-1
Abstract: The case presented here illustrates the hypothesis that its specific pathogenesis is unknown.Mucoepidermoid carcinoma of the jaw is a rare tumour of unknown aetiology. Although about a 100 cases has been reported in literature, the speculation on its aetiopathogenesis has mainly centred on the pluripotential capabilities of the epithelial lining of odontogenic cysts.Mucoepidermoid carcinoma is usually associated with salivary glands and comprises 5–10% of all salivary gland tumours [1-3]. In 1945, Stewart and associates described its mucous-secreting and epidermal cellular elements thus establishing it as a distinct pathologic entity [4]. Eversole reviewed 815 cases and found that of the major salivary gland tumours, 89.6% involved the parotid, 8.4% submandibular and 0.4% sublingual gland [1]. The palate was the most common site for minor salivary gland involvement, accounting for 41.1% of intraoral lesions [1].Aberrant salivary gland neoplasms arising within the jaws as primary central bony lesions are extremely rare comprising 2–3% of all mucoepidermoid carcinomas reported [2]. Lepp in 1939 first reported an intraosseous mucoepidermoid carcinoma of the mandible in a 66-year-old woman [5] and Bhaskar [6] in 1963 reported two cases discussing the criteria for their origin, histological composition and possible explanations for tumour pathogenesis. In 1991, after a systematic review of its histology and degree of differentiation the WHO classification recommended that the term "mucoepidermoid tumour" be changed to "mucoepidermoid carcinoma"[7]. Waldron and Mustoe [8] suggested that intraosseous mucoepidermoid carcinoma be included in primary intraosseous carcinoma of jaw as type 4 (Table 1) [9]. A thorough review of the English literature revealed about 100 reported cases of mucoepidermoid carcinoma arising in mandible [2,3,10,11]. We report here another case of central mucoepidermoid carcinoma within the bony mandible with no initial connection to alveolus.A 67-year
Zeylanidium as Pollution Indicators: Live Sensors to Water Parameters  [PDF]
Thara K. Simon, Veena Mathew, S. L. Sreekala
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104518
Abstract:
Podostemaceae family is well known as a group of aquatic angiosperms with enigmatic characters. The present work was performed to trace ecological aspects, phenology, water analysis and phylogenetic analysis of the genus Zeylanidium, in order to establish the uniqueness of the species in the fresh water habitats S-1 (9.9559°N, 76.8339°E) and S-2 (10.0538°N, 76.8294°E). Through water analysis it is revealed that the species of plants could be used as an indicator of pollution as they are present in very sensitive area of running fresh water. The phenology of the taxa understudy paved light to the co-existence of Zeylanidium maheshwari and Zeylanidium lichenoides. The data on comparison of molecular and phylogenic tree reveal that the species are highly related genetically for a sustainable coexistence.
Unusual presentation of choriocarcinoma
PG Balagopal, Manoj Pandey, K Chandramohan, Thara Somanathan, Ashwin Kumar
World Journal of Surgical Oncology , 2003, DOI: 10.1186/1477-7819-1-4
Abstract: A case of malignant trophoblastic disease with brain metastasis, raised intra cranial pressure and small bowel metastasis presenting with acute abdomen is reported.Malignant transformation in a hydatidiform mole is rare event. Involvement of gastrointestinal tract is rarer even in presence of disseminated disease. Surgery is the treatment of choice for gastrointestinal complications.Trophoblastic diseases comprise a variety of biologically interrelated conditions which form a clinical spectrum consisting of four distinct clinical pathological entities like (1) molar pregnancy (2) invasive mole (3) placental site trophoblastic tumours and (4) choriocarcinoma [1].Incidence of hydatidiform mole ranges from 1 in 500 in India to 1 in 3000 in USA. Like wise malignant potential of the disease is also higher in Southeast Asia reaching as high as 10–15% compared to 2–4% in west. Some of the hydatidiform moles erode the wall of uterus, burrow into myometrium and may even burst though the uterus into peritoneum and are called invasive mole. Even though locally aggressive, invasive mole does not metastasise. On the other hand choriocarcinoma is rare but one of the most malignant neoplasms arising in the body of uterus. choriocarcinoma metastasises readily. It is not uncommon to find secondary nodules in the cervix or vagina. The lungs, brain and liver are the distant organs more often involved. Lymph nodes are rarely the site of metastasis [2]. We report here a case of hydatidiform mole metastasising to brain and later presenting with intestinal metastasis and perforation.A twenty-four-year old housewife underwent dilatation and curettage for vaginal bleeding in 1994. Pathological examination of curettage specimen showed hydatidiform mole. She later conceived and had two normal deliveries. She remained asymptomatic for eight years. In January 2002 she was brought to medical causality with features suggestive of raised intra cranial pressure. A computerised tomographic scan of t
Use of antipsychotics and tardive dyskinesia
Thara R
Journal of Postgraduate Medicine , 2004,
Abstract:
GPU Accelerated Automated Feature Extraction From Satellite Images
K. Phani Tejaswi,D. Shanmukha Rao,Thara Nair,A. V. V. Prasad
International Journal of Distributed and Parallel Systems , 2013,
Abstract: The availability of large volumes of remote sensing data insists on higher degree of automation in featureextraction, making it a need of thehour. Fusingdata from multiple sources, such as panchromatic,hyperspectraland LiDAR sensors, enhances the probability of identifying and extracting features such asbuildings, vegetation or bodies of water by using a combination of spectral and elevation characteristics.Utilizing theaforementioned featuresin remote sensing is impracticable in the absence ofautomation.Whileefforts are underway to reduce human intervention in data processing, this attempt alone may notsuffice. Thehuge quantum of data that needs to be processed entailsaccelerated processing to be enabled.GPUs, which were originally designed to provide efficient visualization,arebeing massively employed forcomputation intensive parallel processing environments. Image processing in general and hence automatedfeatureextraction, is highly computation intensive, where performance improvements have a direct impacton societal needs. In this context, an algorithm has been formulated for automated feature extraction froma panchromatic or multispectral image based on image processing techniques.Two Laplacian of Guassian(LoG)masks were applied on the image individually followed by detection of zero crossing points andextracting the pixels based on their standard deviationwiththe surrounding pixels. The two extractedimages with different LoG masks were combined together which resulted in an image withthe extractedfeatures and edges.Finally the user is at liberty to apply the image smoothing step depending on the noisecontent in the extracted image.The image ispassed through a hybrid median filter toremove the salt andpepper noise from the image.This paper discusses theaforesaidalgorithmforautomated featureextraction, necessity of deployment of GPUs for thesame;system-level challenges and quantifies thebenefits of integrating GPUs in such environment. The results demonstrate that substantial enhancement inperformance margin can be achieved with thebestutilization of GPU resources and an efficientparallelization strategy.Performance results in comparison with the conventional computing scenario haveprovided a speedup of20x, on realization of this parallelizing strategy
Inhibition of Aldose Activity by Essential Phytochemicals of Cymbopogon citratus (DC.) Stapf
P .Vyshali,K.J.Thara Saraswati,Rajeshwari Sanakal,B.B.Kaliwal
International Journal of Biometric and Bioinformatics , 2011,
Abstract: The ambiguity of whether aldose reductase, an enzyme of polyol pathway, is linked to diabetesand its complication has been receded based on the recent studies made on the inhibition of its(Aldose reductase) activity. In our current study, we have used an in silico approach (moleculardocking) to analyze the effect of essential phytochemicals obtained from Cymbopogon citratus onthe aldose reductase activity. C.citratus is grown extensively in tropical countries including Indiafor perfumery and pharmaceuticals. The essential phytochemicals of C.citratus like Myrcene,Citral, and Geraniol have been used as ligand for the molecular docking analysis with Aldosereductase as receptor. The docking analysis showed Myrcene, with binding energy of -8.76Kcal/mol is best amongst Citral and Geraniol which are having binding energies of -7.24 Kcal/moland -7.93 Kcal/mol respectively for inhibiting the activity of Aldose reductase.
GPU Acclerated Automated Feature Extraction from Satellite Images
K. Phani Tejaswi,D. Shanmukha Rao,Thara Nair,A. V. V. Prasad
Computer Science , 2013, DOI: 10.5121/ijdps.2013.4201
Abstract: The availability of large volumes of remote sensing data insists on higher degree of automation in feature extraction, making it a need of the hour.The huge quantum of data that needs to be processed entails accelerated processing to be enabled.GPUs, which were originally designed to provide efficient visualization, are being massively employed for computation intensive parallel processing environments. Image processing in general and hence automated feature extraction, is highly computation intensive, where performance improvements have a direct impact on societal needs. In this context, an algorithm has been formulated for automated feature extraction from a panchromatic or multispectral image based on image processing techniques. Two Laplacian of Guassian (LoG) masks were applied on the image individually followed by detection of zero crossing points and extracting the pixels based on their standard deviation with the surrounding pixels. The two extracted images with different LoG masks were combined together which resulted in an image with the extracted features and edges. Finally the user is at liberty to apply the image smoothing step depending on the noise content in the extracted image. The image is passed through a hybrid median filter to remove the salt and pepper noise from the image. This paper discusses the aforesaid algorithm for automated feature extraction, necessity of deployment of GPUs for the same; system-level challenges and quantifies the benefits of integrating GPUs in such environment. The results demonstrate that substantial enhancement in performance margin can be achieved with the best utilization of GPU resources and an efficient parallelization strategy. Performance results in comparison with the conventional computing scenario have provided a speedup of 20x, on realization of this parallelizing strategy.
Work Motivation of Teachers: Relationship with Organizational Commitment
Louis George,Thara Sabapathy
Canadian Social Science , 2011,
Abstract: : In the modern world of competitive higher education the role of motivated teachers is undeniable. This study aims to find the importance of organizational commitment in motivating the teachers. Data was collected from 450 degree college teachers of Bangalore city. Analysis of data and the discussion is included. The results showed a positive relationship between work motivation and organizational commitment of degree college teachers. More committed teachers were found to be more motivated. Implications of the findings and limitations of the study are given. Key words: Work motivation; Organizational commitment Résumé: Dans le monde moderne de l'enseignement supérieur compétitif le r le des enseignants motivés est indéniable. Cette étude vise à trouver l'importance de l'engagement organisationnel dans la motivation des enseignants. Les données ont été recueillies à partir de 450 enseignants universitaires de la ville de Bangalore. L'analyse des données et la discussion sont inclus. Les résultats ont montré une relation positive entre la motivation au travail et l'engagement organisationnel des enseignants universitaires. Les enseignants qui engagent le plus ont été trouvés à être plus motivés. Implications des conclusions et des limites de l'étude sont donnés. Mots clés: Motivation au travail; Engagement organisationnel
Immune Response to Sipuleucel-T in Prostate Cancer
Eddie Thara,Tanya B. Dorff,Monica Averia-Suboc,Michael Luther,Mary E. Reed,Jacek K. Pinski,David I. Quinn
Cancers , 2012, DOI: 10.3390/cancers4020420
Abstract: Historically, chemotherapy has remained the most commonly utilized therapy in patients with metastatic cancers. In prostate cancer, chemotherapy has been reserved for patients whose metastatic disease becomes resistant to first line castration or androgen deprivation. While chemotherapy palliates, decreases serum prostate specific antigen and improves survival, it is associated with significant side effects and is only suitable for approximately 60% of patients with castrate-resistant prostate cancer. On that basis, exploration of other therapeutic options such as active secondary hormone therapy, bone targeted treatments and immunotherapy are important. Until recently, immunotherapy has had no role in the treatment of solid malignancies aside from renal cancer and melanoma. The FDA-approved autologous cellular immunotherapy sipuleucel-T has demonstrated efficacy in improving overall survival in patients with metastatic castrate-resistant prostate cancer in randomized clinical trials. The proposed mechanism of action is reliant on activating the patients’ own antigen presenting cells (APCs) to prostatic acid phosphatase (PAP) fused with granulocyte-macrophage colony stimulating factor (GM-CSF) and subsequent triggered T-cell response to PAP on the surface of prostate cancer cells in the patients body. Despite significant prolongation of survival in Phase III trials, the challenge to health care providers remains the dissociation between objective changes in serum PSA or on imaging studies after sipleucel-T and survival benefit. On that basis there is an unmet need for markers of outcome and a quest to identify immunologic or clinical surrogates to fill this role. This review focuses on the impact of sipuleucel-T on the immune system, the T and B cells, and their responses to relevant antigens and prostate cancer. Other therapeutic modalities such as chemotherapy, corticosteroids and GM-CSF and host factors can also affect immune response. The optimal timing for immunotherapy, patient selection and best sequencing with other prostate cancer therapies remain to be determined. A better understanding of immune response may help address these issues.
The Cluster Fe2Si18 as the New Quantum Bit System  [PDF]
K. V. Simon, A. V. Tulub
Computational Chemistry (CC) , 2015, DOI: 10.4236/cc.2015.32004
Abstract: Multiconfiguration quantum chemical calculation of geometry and electron properties of Fe2Si18 cluster indicates on the predictable change of spin states as a function of the excitation energy beginning from ground state with the total spin S = 4. The charges on the two Fe atoms are quite different as well as the charge distribution on the surrounding Si atoms. Nevertheless the total dipole moment of the cluster is a monotonically decreasing function of the excitation energy and it reaches practically zero value in the first singlet state in which the cluster represents a new version of a quibit system.
第1页/共147541条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.