%0 Journal Article %T Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors %A Ali Pourzand %A M. Bassir A. Fakhree %A Shahryar Hashemzadeh %A Monireh Halimi and Amir Daryani %J Breast Cancer: Basic and Clinical Research %D 2012 %I %R 10.4137/BCBCR.S7199 %X Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods: We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results: There is a direct correlation between positive progesterone receptor status and being younger than 40 (P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages (P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression (P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions: Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status. %U http://www.la-press.com/hormone-receptor-status-in-breast-cancer-and-its-relation-to-age-and-o-article-a2658